|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4) antibody
|Synonyms||atf-4, MGC68539, zgc:85951, wu:fj01c08, wu:fk30b04, creb2, txreb, creb-2, MGC69565, taxreb67, ATF4, ATF4C, MGC126973, MGC179261, sb:eu681, wu:fb08f07, zgc:171702, CREB2|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||ATF4 (NP_001666, 171 a.a. ~ 271 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: CREB2, CREB2, TAXREB67, TXREBactivating transcription factor 4 (tax-responsive enhancer element B67)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||ATF4 (NP_001666, 171 a.a. ~ 271 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||38590 DA|
Background: This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.Preca|
|Research Area||Transcription Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Afonyushkin, Oskolkova, Philippova et al.: "Oxidized phospholipids regulate expression of ATF4 and VEGF in endothelial cells via NRF2-dependent mechanism: novel point of convergence between electrophilic and unfolded protein stress pathways." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 30, Issue 5, pp. 1007-13, 2010 (PubMed).
Ye, Kumanova, Hart et al.: "The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation." in: The EMBO journal, Vol. 29, Issue 12, pp. 2082-96, 2010 (PubMed).
Rzymski, Milani, Pike et al.: "Regulation of autophagy by ATF4 in response to severe hypoxia." in: Oncogene, Vol. 29, Issue 31, pp. 4424-35, 2010 (PubMed).
Wek, Staschke: "How do tumours adapt to nutrient stress?" in: The EMBO journal, Vol. 29, Issue 12, pp. 1946-7, 2010 (PubMed).
Liew, Bochenski, Kawamori et al.: "The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells." in: The Journal of clinical investigation, Vol. 120, Issue 8, pp. 2876-88, 2010 (PubMed).