LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) antibody

Details for Product No. ABIN394113
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Antigen
Synonyms wu:fc83a08, zgc:111930, LMO-2, lmo2-A, xlmo2, TTG2, RBTN2, RHOM2, RBTNL1, Rbtn-2, Rbtn2, Rhom-2, Ttg2, rhombotin-2
Reactivity
Human
(75), (17), (16), (14), (13), (12), (2), (1), (1)
Host
Mouse
(41), (38), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(49), (39), (15), (11), (10), (7), (6), (5), (1), (1), (1), (1)
Pubmed 5 references available
Catalog no. ABIN394113
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen LMO2 (AAH34041, 1 a.a. ~ 159 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2B3
Isotype IgG1 kappa
Specificity LMO2 (AAH34041, 1 a.a. ~ 159 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name LMO2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18358 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) antibody LMO2 monoclonal antibody (M02), clone 2B3. Western Blot analysis of LMO2 expression in human spleen. LMO2 monoclonal antibody (M02), clone 2B3 Western Blot analysis of LMO2 expression in HL-60.
anti-LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) antibody (2) anti-LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) antibody (Image 2)
Background publications Hosgood, Zhang, Shen et al.: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, 2009 (PubMed).

Sun, Shen, Yang et al.: "Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes." in: Journal of biomedical science, Vol. 17, Issue 1, pp. 22, 2010 (PubMed).

Hirose, Inukai, Kikuchi et al.: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, 2010 (PubMed).

Durnick, Law, Maurer et al.: "Expression of LMO2 is associated with t(14;18)/IGH-BCL2 fusion but not BCL6 translocations in diffuse large B-cell lymphoma." in: American journal of clinical pathology, Vol. 134, Issue 2, pp. 278-81, 2010 (PubMed).

Younes, Beck, Lossos et al.: "Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components." in: The American journal of surgical pathology, Vol. 34, Issue 9, pp. 1266-76, 2010 (PubMed).

Hosts (41), (38), (3)
Reactivities (75), (17), (16), (14), (13), (12), (2), (1), (1)
Applications (49), (39), (15), (11), (10), (7), (6), (5), (1), (1), (1), (1)
Conjugates (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (5), (4), (2), (1)
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