LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) antibody

Antigen: LIM Domain Only 2 (Rhombotin-Like 1) (LMO2)

Synonyms: TTG2, RBTN2, RHOM2, RBTNL1, wu:fc83a08, zgc:111930, MGC124678, MGC139114

Clonality: Monoclonal (2B3)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394113

Additional Information

Alternative name: LMO2

Gene ID: 4005

Immunogen: LMO2 (AAH34041, 1 a.a. ~ 159 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2B3

Description: Other names: RBTN2, RBTNL1, RHOM2, TTG2 LIM domain only 2 (rhombotin-like 1)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: LMO2 (AAH34041, 1 a.a. ~ 159 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 18358 DA

Comments:

Background: LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

LMO2 monoclonal antibody (M02), clone 2B3. Western Blot analysis of LMO2 expression in human spleen. LMO2 monoclonal antibody (M02), clone 2B3 Western Blot analysis of LMO2 expression in HL-60 ( Cat # L014V1 ).

anti-LIM Domain Only 2 (Rhombotin-Like 1) (LMO2) antibody (Image 2)

Publications

Product: Hosgood, Zhang, Shen et al.: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, 2009 (PubMed).

Sun, Shen, Yang et al.: "Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic-related target genes." in: Journal of biomedical science, Vol. 17, Issue 1, pp. 22, 2010 (PubMed).

Hirose, Inukai, Kikuchi et al.: "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription factor and its implication in leukemogenesis of B-precursor ALL with t(17;19)." in: Blood, Vol. 116, Issue 6, pp. 962-70, 2010 (PubMed).

Durnick, Law, Maurer et al.: "Expression of LMO2 is associated with t(14;18)/IGH-BCL2 fusion but not BCL6 translocations in diffuse large B-cell lymphoma." in: American journal of clinical pathology, Vol. 134, Issue 2, pp. 278-81, 2010 (PubMed).

Younes, Beck, Lossos et al.: "Immunoarchitectural patterns in follicular lymphoma: efficacy of HGAL and LMO2 in the detection of the interfollicular and diffuse components." in: The American journal of surgical pathology, Vol. 34, Issue 9, pp. 1266-76, 2010 (PubMed).