|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Inhibitor of Growth Family, Member 3 (ING3) antibody
|Synonyms||Eaf4, ING2, MEAF4, p47ING3, FLJ20089, MGC112729, ing3, MGC52705, MGC56327, zgc:56327, ING3, DKFZp459N2251, P47ING3, 1300013A07Rik|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||ING3 (NP_938008, 1 a.a. ~ 93 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: Eaf4, FLJ20089, ING2, p47ING3 inhibitor of growth family, member 3|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||ING3 (NP_938008, 1 a.a. ~ 93 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||46743 DA|
Background: The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cancer, Signaling, Chromatin, Cell Structure|
|Restrictions||For Research Use only|
Shi, Hong, Walter et al.: "ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression." in: Nature, Vol. 442, Issue 7098, pp. 96-9, 2006 (PubMed).
Wang, Dai, Martinka et al.: "Prognostic significance of nuclear ING3 expression in human cutaneous melanoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 14, pp. 4111-6, 2007 (PubMed).
Gunduz, Beder, Gunduz et al.: "Downregulation of ING3 mRNA expression predicts poor prognosis in head and neck cancer." in: Cancer science, Vol. 99, Issue 3, pp. 531-8, 2008 (PubMed).
Maestrini, Pagnamenta, Lamb et al.: "High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility." in: Molecular psychiatry, Vol. 15, Issue 9, pp. 954-68, 2010 (PubMed).
Chen, Wang, Garate et al.: "The tumor suppressor ING3 is degraded by SCF(Skp2)-mediated ubiquitin-proteasome system." in: Oncogene, Vol. 29, Issue 10, pp. 1498-508, 2010 (PubMed).
|Hosts||Rabbit (14), Goat (4), Mouse (3)|
|Reactivities||Human (19), Mouse (Murine) (11), Rat (Rattus) (10), Chicken (5), Dog (Canine) (4), Cow (Bovine) (3), Xenopus laevis (2), Zebrafish (2), Cat (Feline) (1), Monkey (1), Rabbit (1)|
|Applications||Western Blotting (WB) (19), ELISA (16), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (5), Immunofluorescence (IF) (4), Immunoprecipitation (IP) (2), Immunocytochemistry (ICC) (1)|
|Epitopes||AA 294-304 (1), Internal Region (1), N-Term (1)|