SOX4 (AA 45-137) antibody

Details for Product No. ABIN394134, Supplier: Log in to see
Antigen
  • EVI16
  • AA682046
  • Sox-4
  • sox4
  • wu:fb82f08
  • wu:fq41g10
  • zgc:65850
  • zgc:77392
  • SRY (sex determining region Y)-box 4
  • SRY-box containing gene 4
  • SRY-box containing gene 4a
  • SOX4
  • Sox4
  • sox4a
Epitope
AA 45-137
21
9
5
5
5
4
4
1
1
1
1
1
1
Reactivity
Human
73
25
22
5
5
3
3
2
1
1
1
1
1
Host
Mouse
62
11
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
ELISA
36
21
16
13
13
8
5
3
3
1
Options
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Immunogen SOX4 (NP_003098, 45 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C5
Isotype IgG1 kappa
Specificity SOX4 (NP_003098, 45 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Background This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.
Synonyms: EVI16 SRY (sex determining region Y)-box 4
Molecular Weight 47263 DA
Gene ID 6659
NCBI Accession NP_003098
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-SOX4 (AA 45-137) antibody (ABIN394134) Detection limit for recombinant GST tagged SOX4 is approximately 0.3 ng/mL as a captu...
Background publications Hur, Rhim, Jung, Kim, Bae, Jang, Yang, Oh, Kim, Wang, Lee, Yoon: "SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1298-307, 2010 (PubMed).

Shen, Pan, Qi, Lin, Cheng: "Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 1047-52, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Ragvin, Moro, Fredman, Navratilova, Drivenes, Engström, Alonso, de la Calle Mustienes, Gómez Skarmeta, Tavares, Casares, Manzanares, van Heyningen, Molven, Njølstad, Argenton, Lenhard, Becker: "Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 2, pp. 775-80, 2010 (PubMed).

Iqbal, Otsuyama, Shamsasenjan, Asaoku, Kawano: "CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4." in: International journal of hematology, Vol. 91, Issue 2, pp. 267-75, 2010 (PubMed).