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SOX4 (AA 45-137) antibody

Details for Product No. ABIN394134
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Antigen
Synonyms EVI16, AA682046, Sox-4, sox4, wu:fb82f08, wu:fq41g10, zgc:65850, zgc:77392
Epitope
AA 45-137
(12), (10), (4), (2), (2), (1), (1), (1)
Reactivity
Human
(50), (14), (14), (13), (2), (2), (1)
Host
Mouse
(43), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA
(20), (17), (12), (10), (6), (3), (3), (1), (1)
Pubmed 5 references available
Quantity 0.05 mg
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Catalog No. ABIN394134
450.00 $
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Immunogen SOX4 (NP_003098, 45 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2C5
Isotype IgG1 kappa
Specificity SOX4 (NP_003098, 45 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification Purified
Background This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.
Synonyms: EVI16 SRY (sex determining region Y)-box 4
Molecular Weight 47263 DA
Gene ID 6659
UniProt NP_003098
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Restrictions For Research Use only
Buffer Phosphate buffered saline, pH 7.2
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-SOX4 (AA 45-137) antibody Detection limit for recombinant GST tagged SOX4 is approximately 0.3 ng/mL as a capture antibody.
Background publications Iqbal, Otsuyama, Shamsasenjan et al.: "CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4." in: International journal of hematology, Vol. 91, Issue 2, pp. 267-75, 2010 (PubMed).

Ragvin, Moro, Fredman et al.: "Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 2, pp. 775-80, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Shen, Pan, Qi et al.: "Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 1047-52, 2010 (PubMed).

Hur, Rhim, Jung et al.: "SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1298-307, 2010 (PubMed).

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