SOX4 antibody

Antigen: SOX4

Clonality: Monoclonal (2C5)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN394134

Additional Information

Gene ID: 6659

UniProt: NP_003098

Immunogen: SOX4 (NP_003098, 45 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2C5

Description: Other names: EVI16 SRY (sex determining region Y)-box 4

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: SOX4 (NP_003098, 45 a.a. ~ 137 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 47263 DA

Comments:

Background: This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged SOX4 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Iqbal, Otsuyama, Shamsasenjan et al.: "CD56 expression in human myeloma cells derived from the neurogenic gene expression: possible role of the SRY-HMG box gene, SOX4." in: International journal of hematology, Vol. 91, Issue 2, pp. 267-75, 2010 (PubMed).

Ragvin, Moro, Fredman et al.: "Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 2, pp. 775-80, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Shen, Pan, Qi et al.: "Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 in gastric cancer." in: Biochemical and biophysical research communications, Vol. 394, Issue 4, pp. 1047-52, 2010 (PubMed).

Hur, Rhim, Jung et al.: "SOX4 overexpression regulates the p53-mediated apoptosis in hepatocellular carcinoma: clinical implication and functional analysis in vitro." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1298-307, 2010 (PubMed).