BAG1 antibody (BCL2-Associated Athanogene) (AA 241-346)

Details for Product anti-BAG1 Antibody No. ABIN394144, Supplier: Log in to see
Antigen
  • ATBAG1
  • BCL-2-associated athanogene 1
  • MSG15.15
  • MSG15_15
  • BAG-1
  • HAP
  • RAP46
  • Bag-1
  • Rap46
  • bcl2-associated athanogene
  • BCL2-associated athanogene
  • BCL-2-associated athanogene 1
  • BCL2-associated athanogene 1
  • Protein BAG-1
  • Smp_005900
  • Smp_031560
  • LOC100345469
  • BAG1
  • Bag1
  • bag-1
Epitope
AA 241-346
22
15
7
5
5
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
114
73
58
6
4
3
2
2
1
1
1
Host
Mouse
101
22
Clonality (Clone)
Monoclonal ()
Application
Immunofluorescence (IF), Western Blotting (WB)
121
53
44
35
28
26
8
6
3
2
2
1
1
1
1
Options
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Immunogen BAG1 (NP_004314, 241 a.a. ~ 346 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2D3
Isotype IgG2a kappa
Specificity BAG1 (NP_004314, 241 a.a. ~ 346 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BAG1 (BAG1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 38878 DA
Gene ID 12406
NCBI Accession NP_004314
Research Area Translation Factors, Cell Structure, Signaling
Application Notes Western blot = 1:500-1000
Comment

Background: The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-BAG1 antibody (BCL2-Associated Athanogene) (AA 241-346) (ABIN394144) Immunofluorescence of monoclonal antibody to BAG1 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-BAG1 antibody (BCL2-Associated Athanogene) (AA 241-346) (ABIN394144) anti-BCL2-Associated Athanogene (BAG1) (AA 241-346) antibody (Image 2)
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Deeg, Gralle, Sroka, Bähr, Wouters, Kermer: "BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity." in: The Journal of cell biology, Vol. 188, Issue 4, pp. 505-13, 2010 (PubMed).

Zheng, Xu, Xing, Wei, Takahashi, Masuda, Takano: "Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas." in: Human pathology, Vol. 41, Issue 5, pp. 724-36, 2010 (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).