|+1 404 474 4654|
|+1 888 205 9894 (TF)|
DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 3, Y-Linked (DDX3Y) antibody
|Synonyms||DBY, Dby, D1Pas1-rs1, 8030469F12Rik, DDX3Y, DKFZp469G1332, Ddx3y|
Alternatives ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||DDX3Y (NP_004651, 1 a.a. ~ 81 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: DBY DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||DDX3Y (NP_004651, 1 a.a. ~ 81 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||73154 DA|
Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunohistochemistry ~~ 1.5ug/ml|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Translation Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
Pope, Lee: "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin." in: The Journal of steroid biochemistry and molecular biology, Vol. 94, Issue 1-3, pp. 203-8, 2005 (PubMed).
Jeronimo, Forget, Bouchard et al.: "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme." in: Molecular cell, Vol. 27, Issue 2, pp. 262-74, 2007 (PubMed).
Lardone, Parodi, Valdevenito et al.: "Quantification of DDX3Y, RBMY1, DAZ and TSPY mRNAs in testes of patients with severe impairment of spermatogenesis." in: Molecular human reproduction, Vol. 13, Issue 10, pp. 705-12, 2007 (PubMed).
Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).
Rosinski, Fujii, Mito et al.: "DDX3Y encodes a class I MHC-restricted H-Y antigen that is expressed in leukemic stem cells." in: Blood, Vol. 111, Issue 9, pp. 4817-26, 2008 (PubMed).
|Hosts||Rabbit (11), Mouse (1)|
|Reactivities||Human (12), Mouse (Murine) (4), Rat (Rattus) (3), Cat (Feline) (1), Chicken (1), Cow (Bovine) (1), Dog (Canine) (1)|
|Applications||ELISA (12), Western Blotting (WB) (9), Immunohistochemistry (IHC) (7), Immunofluorescence (IF) (3), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (1), Immunoprecipitation (IP) (1)|
|Epitopes||N-Term (3), N-Term,AA 97-127 (1)|