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Transcription Factor AP-2 beta (Activating Enhancer Binding Protein 2 Beta) (TFAP2B) (AA 73-183) antibody

Details for Product No. ABIN394169
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Antigen
Synonyms
AP-1beta1, AP-2beta, AP-beta1, AP1beta1, AP2beta2, BAD1, BAP, Beta-adaptin, CG12532, Dmel\\CG12532, bap, beta1/2, cg12532, Tcfap2b, TFAP2B, si:dkey-5e16.1, zgc:110163, AI606113, AP-2(beta), E130018K07 ... show more
AP-1beta1, AP-2beta, AP-beta1, AP1beta1, AP2beta2, BAD1, BAP, Beta-adaptin, CG12532, Dmel\\CG12532, bap, beta1/2, cg12532, Tcfap2b, TFAP2B, si:dkey-5e16.1, zgc:110163, AI606113, AP-2(beta), E130018K07Rik, AP-2B, AP2-B, ap-2b, ap2-b, tfap2beta, AP2 show less
Epitope
AA 73-183
(12), (8), (7), (2), (2), (1), (1), (1)
Reactivity
Human
(32), (9), (7), (5), (4), (4), (4), (3), (1)
Host
Mouse
(25), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(33), (16), (4), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394169
450.00 $
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Immunogen TFAP2B (NP_003212, 73 a.a. ~ 183 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2F6
Isotype IgG1 kappa
Specificity TFAP2B (NP_003212, 73 a.a. ~ 183 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TFAP2B
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50474 DA
Gene ID 12406
UniProt NP_003212
Research Area Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Transcription Factor AP-2 beta (Activating Enhancer Binding Protein 2 Beta) (TFAP2B) (AA 73-183) antibody Western Blot analysis of TFAP2B expression in transfected 293T cell line by TFAP2B monoclonal antibody (M02), clone 2F6. Lane 1: TFAP2B transfected lysate(50.474 KDa). Lane 2: Non-transfected lysate.
Background publications Nordquist, Göktürk, Comasco et al.: "The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents." in: Obesity (Silver Spring, Md.), Vol. 17, Issue 9, pp. 1762-7, 2009 (PubMed).

Dagle, Lepp, Cooper et al.: "Determination of genetic predisposition to patent ductus arteriosus in preterm infants." in: Pediatrics, Vol. 123, Issue 4, pp. 1116-23, 2009 (PubMed).

Lindgren, Heid, Randall et al.: "Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution." in: PLoS genetics, Vol. 5, Issue 6, pp. e1000508, 2009 (PubMed).

Nordquist, Göktürk, Comasco et al.: "Transcription factor AP2 beta involved in severe female alcoholism." in: Brain research, Vol. 1305 Suppl, pp. S20-6, 2009 (PubMed).

Hotta, Nakamura, Nakamura et al.: "Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population." in: Journal of human genetics, Vol. 55, Issue 11, pp. 738-42, 2010 (PubMed).

Validation Images
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