Transcription Factor AP-2 beta (Activating Enhancer Binding Protein 2 Beta) (TFAP2B) antibody

Antigen: Transcription Factor AP-2 beta (Activating Enhancer Binding Protein 2 Beta) (TFAP2B)

Synonyms: ADTB2, AP105B, CLAPB1, AP2-BETA, DKFZp781K0743, AP-2beta, AP-beta1, BAD1, bap, beta1/2, cg12532, DmelCG12532, AI788979, 1300012O03Rik, Tfap2b, AI606113, AP-2(beta), E130018K07Rik, TFAP2B, AP2, zgc:110163, si:dkey-5e16.1, Tcfap2b, AP-2B, MGC143301

Clonality: Monoclonal (2F6)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394169

Additional Information

Alternative name: TFAP2B

Gene ID: 7021

UniProt: NP_003212

Immunogen: TFAP2B (NP_003212, 73 a.a. ~ 183 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2F6

Description: Other names: AP2B, AP2B, CHAR transcription factor AP-2 beta (activating enhancer binding protein 2 beta)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: TFAP2B (NP_003212, 73 a.a. ~ 183 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 50474 DA

Comments:

Background: This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives.

Synonyms: ADTB2, AP105B, CLAPB1, AP2-BETA, DKFZp781K0743, AP-2beta, AP-beta1, BAD1, bap, beta1/2, cg12532, DmelCG12532, AI788979, 1300012O03Rik, Tfap2b, AI606113, AP-2(beta), E130018K07Rik, TFAP2B, AP2, zgc:110163, si:dkey-5e16.1, Tcfap2b, AP-2B, MGC143301

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Cycle, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

Western Blot analysis of TFAP2B expression in transfected 293T cell line by TFAP2B monoclonal antibody (M02), clone 2F6. Lane 1: TFAP2B transfected lysate(50.474 KDa). Lane 2: Non-transfected lysate.

Publications

Product: Nordquist, Göktürk, Comasco et al.: "The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents." in: Obesity (Silver Spring, Md.), Vol. 17, Issue 9, pp. 1762-7, 2009 (PubMed).

Dagle, Lepp, Cooper et al.: "Determination of genetic predisposition to patent ductus arteriosus in preterm infants." in: Pediatrics, Vol. 123, Issue 4, pp. 1116-23, 2009 (PubMed).

Lindgren, Heid, Randall et al.: "Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution." in: PLoS genetics, Vol. 5, Issue 6, pp. e1000508, 2009 (PubMed).

Nordquist, Göktürk, Comasco et al.: "Transcription factor AP2 beta involved in severe female alcoholism." in: Brain research, Vol. 1305 Suppl, pp. S20-6, 2009 (PubMed).

Hotta, Nakamura, Nakamura et al.: "Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population." in: Journal of human genetics, Vol. 55, Issue 11, pp. 738-42, 2010 (PubMed).