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Helicase, Lymphoid-Specific (HELLS) (AA 1-349) antibody

Details for Product No. ABIN394178, Supplier: Log in to see
Antigen
  • HELLS
  • cb65
  • pasg
  • sb:cb65
  • sb:cb749
  • im:6911667
  • AI323785
  • E130115I21Rik
  • LSH
  • Lysh
  • PASG
  • YFK8
  • Tbc1d12
  • SMARCA6
  • lsh
  • nbla10143
  • smarca6
Epitope
AA 1-349
6
6
3
2
1
1
1
1
Reactivity
Human
46
21
20
1
1
1
Host
Mouse
37
9
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
33
11
10
9
7
7
5
3
2
1
1
Supplier
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Immunogen HELLS (AAH30963, 1 a.a. ~ 349 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G10
Isotype IgG1 kappa
Specificity HELLS (AAH30963, 1 a.a. ~ 349 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HELLS (HELLS Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 97074 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Helicase, Lymphoid-Specific (HELLS) (AA 1-349) antibody (ABIN394178) HELLS monoclonal antibody (M04), clone 2G10 Western Blot analysis of HELLS expression...
Background publications Zhou, Han, Li et al.: "Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts." in: Nucleic acids research, Vol. 37, Issue 15, pp. 5183-96, 2009 (PubMed).

Palmieri, Wilson, Iversen et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. ..." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, 2008 (PubMed).

Suzuki, Farrar, Yegnasubramanian et al.: "Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts." in: Epigenetics : official journal of the DNA Methylation Society, Vol. 3, Issue 5, pp. 281-91, 2008 (PubMed).

Myant, Stancheva: "LSH cooperates with DNA methyltransferases to repress transcription." in: Molecular and cellular biology, Vol. 28, Issue 1, pp. 215-26, 2007 (PubMed).

Jeronimo, Forget, Bouchard et al.: "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme." in: Molecular cell, Vol. 27, Issue 2, pp. 262-74, 2007 (PubMed).