Helicase, Lymphoid-Specific (HELLS) antibody

Details for Product No. ABIN394178
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Synonyms LSH, PASG, SMARCA6, lsh, nbla10143, pasg, smarca6, AI323785, E130115I21Rik, Lysh, YFK8, Tbc1d12, HELLS, cb65, sb:cb65, sb:cb749, im:6911667
(29), (16), (15), (13), (12), (1), (1)
(24), (6)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(21), (10), (10), (4), (4), (3), (3), (2), (1)
Pubmed 5 references available
Catalog no. ABIN394178
Quantity 0.1 mg
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Immunogen HELLS (AAH30963, 1 a.a. ~ 349 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G10
Isotype IgG1 kappa
Specificity HELLS (AAH30963, 1 a.a. ~ 349 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HELLS
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 97074 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Helicase, Lymphoid-Specific (HELLS) antibody HELLS monoclonal antibody (M04), clone 2G10 Western Blot analysis of HELLS expression in HeLa NE.
Background publications Jeronimo, Forget, Bouchard et al.: "Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme." in: Molecular cell, Vol. 27, Issue 2, pp. 262-74, 2007 (PubMed).

Myant, Stancheva: "LSH cooperates with DNA methyltransferases to repress transcription." in: Molecular and cellular biology, Vol. 28, Issue 1, pp. 215-26, 2007 (PubMed).

Suzuki, Farrar, Yegnasubramanian et al.: "Stable knockdown of PASG enhances DNA demethylation but does not accelerate cellular senescence in TIG-7 human fibroblasts." in: Epigenetics : official journal of the DNA Methylation Society, Vol. 3, Issue 5, pp. 281-91, 2008 (PubMed).

Palmieri, Wilson, Iversen et al.: "Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 17, Issue 12, pp. 3567-72, 2008 (PubMed).

Zhou, Han, Li et al.: "Senescence delay and repression of p16INK4a by Lsh via recruitment of histone deacetylases in human diploid fibroblasts." in: Nucleic acids research, Vol. 37, Issue 15, pp. 5183-96, 2009 (PubMed).

Hosts (24), (6)
Reactivities (29), (16), (15), (13), (12), (1), (1)
Applications (21), (10), (10), (4), (4), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (2), (1), (1), (1)
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