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TAR (HIV-1) RNA Binding Protein 2 (TARBP2) (AA 141-251) antibody

Details for Product No. ABIN394180
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Antigen
Synonyms trbp, trbp1, trbp2, MGC97783, TARBP2, LOQS, TRBP, TRBP1, TRBP2, fj51e12, wu:fj51e12, zgc:63778, Prbp
Epitope
AA 141-251
(8), (7), (6), (4), (4), (4), (3), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(56), (13), (5), (4), (4), (2), (1), (1), (1)
Host
Mouse
(35), (22)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(56), (36), (11), (10), (8), (6), (4)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394180
450.00 $
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Immunogen TARBP2 (NP_599150, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G10
Isotype IgG1 kappa
Specificity TARBP2 (NP_599150, 141 a.a. ~ 251 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name TARBP2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 39073 DA
Gene ID 12406
UniProt NP_599150
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene also has a pseudogene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-TAR (HIV-1) RNA Binding Protein 2 (TARBP2) (AA 141-251) antibody TARBP2 monoclonal antibody (M04), clone 2G10. Western Blot analysis of TARBP2 expression in Hela NE.
Background publications Daniels, Melendez-Peña, Scarborough et al.: "Characterization of the TRBP domain required for dicer interaction and function in RNA interference." in: BMC molecular biology, Vol. 10, pp. 38, 2009 (PubMed).

Wang, Noland, Siridechadilok et al.: "Structural insights into RNA processing by the human RISC-loading complex." in: Nature structural & molecular biology, Vol. 16, Issue 11, pp. 1148-53, 2009 (PubMed).

Lau, Potter, Carragher et al.: "Structure of the human Dicer-TRBP complex by electron microscopy." in: Structure (London, England : 1993), Vol. 17, Issue 10, pp. 1326-32, 2009 (PubMed).

Wilker, Baccarelli, Suh et al.: "Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes." in: Environmental health perspectives, Vol. 118, Issue 7, pp. 943-8, 2010 (PubMed).

Boni, Zarate, Villa et al.: "Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 429-36, 2011 (PubMed).

Validation Images
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