GATA Binding Protein 2 (GATA2) (AA 1-103) antibody

Details for Product No. ABIN394181
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Antigen
Synonyms GATA2, Gata2, DCML, MONOMAC, NFE1B, xgata-2, xgata2, GATA-2, NF-E1b, Gata-2
Epitope
AA 1-103
(24), (11), (8), (7), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(87), (25), (24), (21), (13), (13), (1), (1), (1)
Host
Mouse
(64), (23), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(65), (35), (20), (18), (14), (13), (10), (6), (2), (2), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394181
450.00 $
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Immunogen GATA2 (AAH18988, 1 a.a. ~ 103 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G11
Isotype IgG Mix kappa
Specificity GATA2 (AAH18988, 1 a.a. ~ 103 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GATA2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 50396 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-GATA Binding Protein 2 (GATA2) (AA 1-103) antibody Immunofluorescence of monoclonal antibody to GATA2 on HeLa cell (antibody concentration 10 µg/mL). GATA2 monoclonal antibody (M04), clone 2G11 Western Blot analysis of GATA2 expression in Hela NE.
anti-GATA Binding Protein 2 (GATA2) (AA 1-103) antibody (2) anti-GATA Binding Protein 2 (GATA2) (AA 1-103) antibody (Image 2)
Background publications Dandona, Chen, Fan et al.: "The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank Studies." in: Human genetics, Vol. 127, Issue 1, pp. 101-5, 2010 (PubMed).

Talmud, Drenos, Shah et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, 2009 (PubMed).

Fujiwara, OGeen, Keles et al.: "Discovering hematopoietic mechanisms through genome-wide analysis of GATA factor chromatin occupancy." in: Molecular cell, Vol. 36, Issue 4, pp. 667-81, 2009 (PubMed).

Shimahara, Yamakawa, Nishikata et al.: "Acetylation of lysine 564 adjacent to the C-terminal binding protein-binding motif in EVI1 is crucial for transcriptional activation of GATA2." in: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 16967-77, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Validation Images
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