Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2) (AA 117-218) antibody

Details for Product No. ABIN394185
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Antigen
Synonyms fa26a01, fc58a11, CHUNP6883, wu:fa26a01, wu:fc58a11, cct2, MGC89448, CCT2, 99D8.1, CCT-beta, CCTB, PRO1633, TCP-1-beta, Cctb
Epitope
AA 117-218
(15), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(47), (23), (22), (14), (14), (14), (14), (5), (3), (2), (2), (2), (1), (1)
Host
Mouse
(27), (17), (8)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(42), (17), (10), (8), (7), (6), (5), (4), (4), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394185
450.00 $
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Immunogen CCT2 (NP_006422, 117 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G6
Isotype IgG1 kappa
Specificity CCT2 (NP_006422, 117 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCT2
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57488 DA
Gene ID 12406
NCBI Accession NP_006422
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2) (AA 117-218) antibody Immunofluorescence of monoclonal antibody to CCT2 on A-431 cell (antibody concentration 10 µg/mL). CCT2 monoclonal antibody (M01), clone 2G6 Western Blot analysis of CCT2 expression in A-431.
anti-Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2) (AA 117-218) antibody (2) anti-Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2) (AA 117-218) antibody (Image 2)
Background publications Goudreault, DAmbrosio, Kean et al.: "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 1, pp. 157-71, 2009 (PubMed).

Abe, Yoon, Kubota et al.: "p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14939-48, 2009 (PubMed).

Oguri, Kato, Yokoi et al.: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Yoshida, Kato, Yokoi et al.: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Fislová, Thomas, Graef et al.: "Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT." in: Journal of virology, Vol. 84, Issue 17, pp. 8691-9, 2010 (PubMed).

Validation Images
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