CCT2 antibody (Chaperonin Containing TCP1, Subunit 2 (Beta)) (AA 117-218)

Details for Product anti-CCT2 Antibody No. ABIN394185, Supplier: Log in to see
Antigen
  • fa26a01
  • fc58a11
  • CHUNP6883
  • wu:fa26a01
  • wu:fc58a11
  • cct2
  • MGC89448
  • CCT2
  • 99D8.1
  • CCT-beta
  • CCTB
  • PRO1633
  • TCP-1-beta
  • Cctb
  • chaperonin containing TCP1, subunit 2 (beta)
  • chaperonin containing Tcp1, subunit 2 (beta)
  • Protein CCT-2
  • CCT2
  • cct2
  • Cct2
  • cct-2
Epitope
AA 117-218
5
3
3
3
1
1
1
1
1
1
1
1
1
Reactivity
Human
81
56
50
18
16
16
13
12
10
8
7
6
6
5
4
3
2
1
1
1
1
1
1
Host
Mouse
44
30
12
Clonality (Clone)
Monoclonal ()
Conjugate
This CCT2 antibody is un-conjugated
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
73
26
20
19
15
13
8
6
2
2
2
1
1
1
1
Options
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Immunogen CCT2 (NP_006422, 117 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G6
Isotype IgG1 kappa
Specificity CCT2 (NP_006422, 117 a.a. ~ 218 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCT2 (CCT2 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 57488 DA
Gene ID 12406
NCBI Accession NP_006422
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of the gene described in this record have been observed but have not been thoroughly characterized.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CCT2 antibody (Chaperonin Containing TCP1, Subunit 2 (Beta)) (AA 117-218) (ABIN394185) Immunofluorescence of monoclonal antibody to CCT2 on A-431 cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-CCT2 antibody (Chaperonin Containing TCP1, Subunit 2 (Beta)) (AA 117-218) (ABIN394185) anti-Chaperonin Containing TCP1, Subunit 2 (Beta) (CCT2) (AA 117-218) antibody (Image 2)
Background publications Fislová, Thomas, Graef, Fodor: "Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT." in: Journal of virology, Vol. 84, Issue 17, pp. 8691-9, 2010 (PubMed).

Yoshida, Kato, Yokoi, Oguri, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nozawa, Yamada: "Association of genetic variants with hemorrhagic stroke in Japanese individuals." in: International journal of molecular medicine, Vol. 25, Issue 4, pp. 649-56, 2010 (PubMed).

Oguri, Kato, Yokoi, Yoshida, Watanabe, Metoki, Yoshida, Satoh, Aoyagi, Nozawa, Yamada: "Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals." in: American journal of hypertension, Vol. 23, Issue 1, pp. 70-7, 2009 (PubMed).

Abe, Yoon, Kubota, Mendoza, Gygi, Blenis: "p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling." in: The Journal of biological chemistry, Vol. 284, Issue 22, pp. 14939-48, 2009 (PubMed).

Goudreault, DAmbrosio, Kean, Mullin, Larsen, Sanchez, Chaudhry, Chen, Sicheri, Nesvizhskii, Aebersold, Raught, Gingras: "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 1, pp. 157-71, 2009 (PubMed).