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Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein (ID3) (AA 1-84) antibody

Details for Product No. ABIN394200, Supplier: Login to see
Antigen
  • ID3
  • MOR136-6
  • fa56g03
  • tdsubc_2g3
  • wu:fa56g03
  • ik:tdsubc_2g3
  • xx:tdsubc_2g3
  • heir-1
  • xid3
  • xidia
  • Hlh462
  • Idb3
  • bHLHb25
  • HEIR-1
Epitope
AA 1-84
25
19
15
15
6
6
5
2
2
2
2
2
1
1
Reactivity
Human
127
26
20
2
1
1
Host
Mouse
74
57
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
94
45
37
27
24
23
11
9
8
4
2
1
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Immunogen ID3 (NP_002158, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2H8
Isotype IgG2a kappa
Specificity ID3 (NP_002158, 1 a.a. ~ 84 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ID3 (ID3 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 12969 DA
Gene ID 12406
NCBI Accession NP_002158
Research Area Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein (ID3) (AA 1-84) antibody (ABIN394200) Immunofluorescence of monoclonal antibody to ID3 on HeLa cell (antibody concentration...
Immunohistochemistry (IHC) image for anti-Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein (ID3) (AA 1-84) antibody (ABIN394200) anti-Inhibitor of DNA Binding 3, Dominant Negative Helix-Loop-Helix Protein (ID3) (AA 1-84) antibody (Image 2)
Background publications Doran, Lehtinen, Meller et al.: "Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans." in: Circulation research, Vol. 106, Issue 7, pp. 1303-11, 2010 (PubMed).

McGeachie, Ramoni, Mychaleckyj et al.: "Integrative predictive model of coronary artery calcification in atherosclerosis." in: Circulation, Vol. 120, Issue 24, pp. 2448-54, 2009 (PubMed).

Shuno, Tsuno, Okaji et al.: "Id1/Id3 knockdown inhibits metastatic potential of pancreatic cancer." in: The Journal of surgical research, Vol. 161, Issue 1, pp. 76-82, 2010 (PubMed).

Higgins, Wong, Richner et al.: "Fibroblast growth factor 2 reactivates G1 checkpoint in SK-N-MC cells via regulation of p21, inhibitor of differentiation genes (Id1-3), and epithelium-mesenchyme transition-like events." in: Endocrinology, Vol. 150, Issue 9, pp. 4044-55, 2009 (PubMed).

Trabosh, Daher, Divito et al.: "UVB upregulates the bax promoter in immortalized human keratinocytes via ROS induction of Id3." in: Experimental dermatology, Vol. 18, Issue 4, pp. 387-95, 2009 (PubMed).