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Interleukin 20 (IL20) (AA 67-177) antibody

Details for Product No. ABIN394201, Supplier: Log in to see
Antigen
  • IL-20
  • IL10D
  • IL20
  • Zcyto10
  • ZCYTO10
Epitope
AA 67-177
22
10
3
2
2
1
1
1
1
1
1
Reactivity
Human
85
22
15
Host
Mouse
35
34
16
2
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
3
3
2
2
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
64
36
12
6
6
4
3
3
2
1
1
1
Supplier
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Immunogen IL20 (NP_061194, 67 a.a. ~ 177 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2H8
Isotype IgG1 kappa
Specificity IL20 (NP_061194, 67 a.a. ~ 177 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL20 (IL20 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20072 DA
Gene ID 12406
NCBI Accession NP_061194
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Interleukin 20 (IL20) (AA 67-177) antibody (ABIN394201) IL20 monoclonal antibody (M01), clone 2H8 Western Blot analysis of IL20 expression in...
Immunohistochemistry (IHC) image for anti-Interleukin 20 (IL20) (AA 67-177) antibody (ABIN394201) anti-Interleukin 20 (IL20) (AA 67-177) antibody (Image 2)
Background publications Schuurhof, Bont, Siezen, Hodemaekers, van Houwelingen, Kimman, Hoebee, Kimpen, Janssen: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, 2010 (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

He, Liang: "IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 4, pp. 1793-8, 2010 (PubMed).

Novakova, Hubackova, Kosar, Janderova-Rossmeislova, Dobrovolna, Vasicova, Vancurova, Horejsi, Hozak, Bartek, Hodny: "Cytokine expression and signaling in drug-induced cellular senescence." in: Oncogene, Vol. 29, Issue 2, pp. 273-84, 2010 (PubMed).

Wolk, Witte, Warszawska, Schulze-Tanzil, Witte, Philipp, Kunz, Döcke, Asadullah, Volk, Sterry, Sabat: "The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis." in: European journal of immunology, Vol. 39, Issue 12, pp. 3570-81, 2009 (PubMed).