Interleukin 20 (IL20) antibody

Antigen: Interleukin 20 (IL20)

Synonyms: IL-20, IL10D, ZCYTO10, MGC96907, IL-17B, ZCYTO7, MGC138900, MGC138901, Zcyto10, MGC130536, IL20

Clonality: Monoclonal (2H8)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394201

Additional Information

Alternative name: IL20

Gene ID: 50604

UniProt: NP_061194

Immunogen: IL20 (NP_061194, 67 a.a. ~ 177 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG1 kappa

Clone: 2H8

Description: Other names: IL20, IL10D, MGC96907, ZCYTO10 interleukin 20

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: IL20 (NP_061194, 67 a.a. ~ 177 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 20072 DA

Comments:

Background: The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

IL20 monoclonal antibody (M01), clone 2H8 Western Blot analysis of IL20 expression in K-562 ( Cat # L009V1 ). IL20 monoclonal antibody (M01), clone 2H8. Western Blot analysis of IL20 expression in A-431 ( Cat # L015V1 ).

anti-Interleukin 20 (IL20) antibody (Image 2)

Publications

Product: Novakova, Hubackova, Kosar et al.: "Cytokine expression and signaling in drug-induced cellular senescence." in: Oncogene, Vol. 29, Issue 2, pp. 273-84, 2010 (PubMed).

Wolk, Witte, Warszawska et al.: "The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis." in: European journal of immunology, Vol. 39, Issue 12, pp. 3570-81, 2009 (PubMed).

He, Liang: "IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 4, pp. 1793-8, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Schuurhof, Bont, Siezen et al.: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, 2010 (PubMed).