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Details for Product No. ABIN394201

Interleukin 20 (IL20) antibody

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Antigen
Synonyms IL-20, IL10D, ZCYTO10, Zcyto10, IL20
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394201
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen IL20 (NP_061194, 67 a.a. ~ 177 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2H8
Isotype IgG1 kappa
Specificity IL20 (NP_061194, 67 a.a. ~ 177 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name IL20
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 20072 DA
Gene ID 12406
UniProt NP_061194
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Novakova, Hubackova, Kosar et al.: "Cytokine expression and signaling in drug-induced cellular senescence." in: Oncogene, Vol. 29, Issue 2, pp. 273-84, 2010 (PubMed).

Wolk, Witte, Warszawska et al.: "The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis." in: European journal of immunology, Vol. 39, Issue 12, pp. 3570-81, 2009 (PubMed).

He, Liang: "IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 4, pp. 1793-8, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Schuurhof, Bont, Siezen et al.: "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls." in: Pediatric pulmonology, Vol. 45, Issue 6, pp. 608-13, 2010 (PubMed).

Alternatives for antigen "Interleukin 20 (IL20)", type "Antibodies"
Hosts (21), (10), (5)
Reactivities (35), (18), (12)
Applications (24), (21), (10), (3), (1), (1), (1), (1)
Conjugates (5), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (4), (1), (1), (1), (1)
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