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VAV1 antibody (Vav 1 Oncogene) (AA 681-791)

Details for Product anti-VAV1 Antibody No. ABIN394203, Supplier: Log in to see
Antigen
  • VAV
  • Vav
  • vav-T
Alternatives
anti-Human VAV1 antibody for Western Blotting
Epitope
AA 681-791
34
21
19
15
13
11
5
4
4
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human
137
63
61
1
1
1
Host
Mouse
125
12
Clonality (Clone)
Monoclonal ()
Conjugate
This VAV1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
115
56
23
12
8
8
6
3
1
1
1
Supplier
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Immunogen VAV1 (AAH13361, 681 a.a. ~ 791 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3A11
Isotype IgG2a kappa
Specificity VAV1 (AAH13361, 681 a.a. ~ 791 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name VAV1 (VAV1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 98314 DA
Gene ID 12406
Research Area Cell Signaling, Transcription Factors, Signaling, Cell Structure
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-VAV1 antibody (Vav 1 Oncogene) (AA 681-791) (ABIN394203) Immunofluorescence of monoclonal antibody to VAV1 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-VAV1 antibody (Vav 1 Oncogene) (AA 681-791) (ABIN394203) anti-Vav 1 Oncogene (VAV1) (AA 681-791) antibody (Image 2)
Background publications Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Barda-Saad, Shirasu, Pauker, Hassan, Perl, Balbo, Yamaguchi, Houtman, Appella, Schuck, Samelson: "Cooperative interactions at the SLP-76 complex are critical for actin polymerization." in: The EMBO journal, Vol. 29, Issue 14, pp. 2315-28, 2010

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010

Kim, Das, Gross, Bryceson, Long: "Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase." in: Immunity, Vol. 32, Issue 2, pp. 175-86, 2010

Yu, Martins, Li, Amarasinghe, Umetani, Fernandez-Zapico, Billadeau, Machius, Tomchick, Rosen: "Structural and energetic mechanisms of cooperative autoinhibition and activation of Vav1." in: Cell, Vol. 140, Issue 2, pp. 246-56, 2010