Homeobox Protein OTX1 antibody

Antigen: Homeobox Protein OTX1

Synonyms: jv, A730044F23Rik, OTX1X

Clonality: Monoclonal (3A5)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394209

Additional Information

Alternative name: OTX1

Gene ID: 5013

UniProt: NP_055377

Immunogen: OTX1 (NP_055377, 10 a.a. ~ 117 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG2a kappa

Clone: 3A5

Description: Other names: FLJ38361, MGC15736 orthodenticle homolog 1 (Drosophila)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: OTX1 (NP_055377, 10 a.a. ~ 117 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 37327 DA

Comments:

Background: This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged OTX1 is approximately 0.03ng/ml as a capture antibody.

Publications

Product: Larsen, Lutterodt, Rath et al.: "Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina." in: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, Vol. 27, Issue 5, pp. 485-92, 2009 (PubMed).

Xin, Rual, Hirozane-Kishikawa et al.: "Shifted Transversal Design smart-pooling for high coverage interactome mapping." in: Genome research, Vol. 19, Issue 7, pp. 1262-9, 2009 (PubMed).

Eeles, Kote-Jarai, Al Olama et al.: "Identification of seven new prostate cancer susceptibility loci through a genome-wide association study." in: Nature genetics, Vol. 41, Issue 10, pp. 1116-21, 2009 (PubMed).

Omodei, Acampora, Russo et al.: "Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma." in: The American journal of pathology, Vol. 175, Issue 6, pp. 2609-17, 2009 (PubMed).

Larsen, Lutterodt, Møllgård et al.: "Expression of the homeobox genes OTX2 and OTX1 in the early developing human brain." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 58, Issue 7, pp. 669-78, 2010 (PubMed).