Aryl Hydrocarbon Receptor (AHR) (AA 721-821) antibody

Details for Product No. ABIN394219
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Antigen
Synonyms AHR, ahr1, ahr, bHLHe76, Ah, Ahh, Ahre, In
Epitope
AA 721-821
(19), (17), (13), (12), (6), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(118), (63), (51), (2), (1), (1), (1)
Host
Mouse
(106), (16), (6), (4)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(91), (55), (42), (37), (23), (19), (13), (10), (9), (8), (3), (2), (2), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394219
450.00 $
Plus shipping costs $45.00

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Immunogen AHR (NP_001612, 721 a.a. ~ 821 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B12
Isotype IgG1 kappa
Specificity AHR (NP_001612, 721 a.a. ~ 821 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AHR
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 96147 DA
Gene ID 12406
NCBI Accession NP_001612
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Aryl Hydrocarbon Receptor (AHR) (AA 721-821) antibody Immunofluorescence of monoclonal antibody to AHR on HeLa cell (antibody concentration 10 µg/mL). Western blot analysis of AHR over-expressed 293 cell line, cotransfected with AHR Validated Chimera RNAi used as specificity and loading control.
anti-Aryl Hydrocarbon Receptor (AHR) (AA 721-821) antibody (2) anti-Aryl Hydrocarbon Receptor (AHR) (AA 721-821) antibody (Image 2)
Background publications Rowlands, Staskal, Gollapudi et al.: "The human AHR: identification of single nucleotide polymorphisms from six ethnic populations." in: Pharmacogenetics and genomics, Vol. 20, Issue 5, pp. 283-90, 2010 (PubMed).

Liu, Wu, Chen et al.: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Tan, Wang, Yang et al.: "Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2)." in: Molecular pharmacology, Vol. 78, Issue 2, pp. 175-85, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Gandhi, Kumar, Burns et al.: "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells." in: Nature immunology, Vol. 11, Issue 9, pp. 846-53, 2010 (PubMed).

Validation Images
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