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SAV1 antibody (Salvador Homolog 1 (Drosophila)) (AA 300-384)

Details for Product anti-SAV1 Antibody No. ABIN394223, Supplier: Log in to see
Antigen
  • SAV
  • WW45
  • WWP4
  • 1700040G09Rik
  • Salv
  • Sav
  • Wwp3
  • Wwp4
Epitope
AA 300-384
19
14
8
6
4
4
3
3
3
2
1
1
Reactivity
Human
51
6
3
1
1
1
1
1
1
Host
Mouse
30
12
10
Clonality (Clone)
Monoclonal ()
Conjugate
This SAV1 antibody is un-conjugated
3
3
3
3
3
3
Application
Immunofluorescence (IF), Western Blotting (WB)
36
32
4
3
3
2
Supplier
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Immunogen SAV1 (NP_068590, 300 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B2
Isotype IgG2a kappa
Specificity SAV1 (NP_068590, 300 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SAV1 (SAV1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44634 DA
Gene ID 12406
NCBI Accession NP_068590
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SAV1 antibody (Salvador Homolog 1 (Drosophila)) (AA 300-384) (ABIN394223) Immunofluorescence of monoclonal antibody to SAV1 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-SAV1 antibody (Salvador Homolog 1 (Drosophila)) (AA 300-384) (ABIN394223) anti-Salvador Homolog 1 (Drosophila) (SAV1) (AA 300-384) antibody (Image 2)
Background publications Luo, Li, Yan et al.: "The human WW45 protein enhances MST1-mediated apoptosis in vivo." in: International journal of molecular medicine, Vol. 23, Issue 3, pp. 357-62, 2009 (PubMed).

Callus, Verhagen, Vaux: "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation." in: The FEBS journal, Vol. 273, Issue 18, pp. 4264-76, 2006 (PubMed).

Benzinger, Muster, Koch et al.: "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 6, pp. 785-95, 2005 (PubMed).

Chan, Nousiainen, Chalamalasetty et al.: "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1." in: Oncogene, Vol. 24, Issue 12, pp. 2076-86, 2005 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).