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Salvador Homolog 1 (Drosophila) (SAV1) (AA 300-384) antibody

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Synonyms SAV, WW45, WWP4, 1700040G09Rik, Salv, Sav, Wwp3, Wwp4
AA 300-384
(19), (14), (8), (6), (4), (4), (3), (3), (3), (2), (1), (1)
(51), (6), (3), (1), (1), (1), (1), (1), (1)
(30), (12), (10)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (3), (3), (3)
Immunofluorescence (IF), Western Blotting (WB)
(36), (32), (4), (3), (3), (2)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen SAV1 (NP_068590, 300 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3B2
Isotype IgG2a kappa
Specificity SAV1 (NP_068590, 300 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SAV1 (SAV1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 44634 DA
Gene ID 12406
NCBI Accession NP_068590
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Salvador Homolog 1 (Drosophila) (SAV1) (AA 300-384) antibody (ABIN394223) Immunofluorescence of monoclonal antibody to SAV1 on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-Salvador Homolog 1 (Drosophila) (SAV1) (AA 300-384) antibody (ABIN394223) anti-Salvador Homolog 1 (Drosophila) (SAV1) (AA 300-384) antibody (Image 2)
Background publications Luo, Li, Yan et al.: "The human WW45 protein enhances MST1-mediated apoptosis in vivo." in: International journal of molecular medicine, Vol. 23, Issue 3, pp. 357-62, 2009 (PubMed).

Callus, Verhagen, Vaux: "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation." in: The FEBS journal, Vol. 273, Issue 18, pp. 4264-76, 2006 (PubMed).

Benzinger, Muster, Koch et al.: "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 6, pp. 785-95, 2005 (PubMed).

Chan, Nousiainen, Chalamalasetty et al.: "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1." in: Oncogene, Vol. 24, Issue 12, pp. 2076-86, 2005 (PubMed).

Gerhard, Wagner, Feingold et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." in: Genome research, Vol. 14, Issue 10B, pp. 2121-7, 2004 (PubMed).

Catalog No. ABIN394223
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