|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Salvador Homolog 1 (Drosophila) (SAV1) antibody
|Synonyms||SAV, WW45, WWP4|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||SAV1 (NP_068590, 300 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: SAV, WW45, WWP4, salvador salvador homolog 1 (Drosophila)|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||SAV1 (NP_068590, 300 a.a. ~ 384 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||44634 DA|
Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a coiled-coil region. It is ubiquitously expressed in adult tissues. The encoded protein is 94% identical to the mouse protein at the amino acid level.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Transcription Factors, Signaling, Cell Structure|
|Restrictions||For Research Use only|
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Chan, Nousiainen, Chalamalasetty et al.: "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1." in: Oncogene, Vol. 24, Issue 12, pp. 2076-86, 2005 (PubMed).
Benzinger, Muster, Koch et al.: "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 6, pp. 785-95, 2005 (PubMed).
Callus, Verhagen, Vaux: "Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation." in: The FEBS journal, Vol. 273, Issue 18, pp. 4264-76, 2006 (PubMed).
Luo, Li, Yan et al.: "The human WW45 protein enhances MST1-mediated apoptosis in vivo." in: International journal of molecular medicine, Vol. 23, Issue 3, pp. 357-62, 2009 (PubMed).