NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody

Details for Product No. ABIN394230, Supplier: Log in to see
Antigen
  • Xbagpipe
  • Xbap
  • bagpipe
  • koza
  • nkx3-1
  • nkx3.1
  • si:ch211-67o1.2
  • nkx3a
  • MGC53041
  • MGC97890
  • Bax
  • NKX3.1
  • NKX3A
  • Nkx-3.1
  • BAPX2
  • NKX3
  • NK3 homeobox 1
  • NK-3 transcription factor, locus 1 (Drosophila)
  • nkx3-1-a
  • NKX3-1
  • nkx3-1
  • LOC100354093
  • Nkx3-1
Alternatives
anti-Mouse (Murine) NK3 Homeobox 1 antibody for Western Blotting
Epitope
AA 100-210
17
16
15
14
13
8
8
7
7
6
5
5
4
3
1
1
1
1
1
1
1
Reactivity
Human
176
50
25
4
4
4
2
2
2
2
1
1
Host
Mouse
111
102
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
8
8
7
7
7
2
2
2
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
184
82
49
48
19
16
4
4
3
2
2
1
Options
Supplier
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Supplier Product No.
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Immunogen NKX3-1 (NP_006158, 100 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C1
Isotype IgG2b kappa
Specificity NKX3-1 (NP_006158, 100 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NKX3-1 (NKX3-1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26350 DA
Gene ID 12406
NCBI Accession NP_006158
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Pathways Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody (ABIN394230) Detection limit for recombinant GST tagged NKX3-1 is approximately 1 ng/mL as a captu...
Background publications Gurel, Ali, Montgomery, Begum, Hicks, Goggins, Eberhart, Clark, Bieberich, Epstein, De Marzo: "NKX3.1 as a marker of prostatic origin in metastatic tumors." in: The American journal of surgical pathology, Vol. 34, Issue 8, pp. 1097-105, 2010 (PubMed).

Kim, Cheng, Hsu, Jin, Kader, Zheng, Isaacs, Xu, Sun: "Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation." in: The Prostate, Vol. 70, Issue 16, pp. 1729-38, 2010 (PubMed).

Kunderfranco, Mello-Grand, Cangemi, Pellini, Mensah, Albertini, Malek, Chiorino, Catapano, Carbone: "ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer." in: PLoS ONE, Vol. 5, Issue 5, pp. e10547, 2010 (PubMed).

Bowen, Gelmann: "NKX3.1 activates cellular response to DNA damage." in: Cancer research, Vol. 70, Issue 8, pp. 3089-97, 2010 (PubMed).

Thomas, Preece, Bentel: "Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region." in: The Biochemical journal, Vol. 425, Issue 3, pp. 575-83, 2010 (PubMed).

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