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NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody

Details for Product No. ABIN394230, Supplier: Log in to see
Antigen
  • Xbagpipe
  • Xbap
  • bagpipe
  • koza
  • nkx3-1
  • nkx3.1
  • si:ch211-67o1.2
  • nkx3a
  • MGC53041
  • MGC97890
  • Bax
  • NKX3.1
  • NKX3A
  • Nkx-3.1
  • BAPX2
  • NKX3
Epitope
AA 100-210
24
19
18
16
15
14
6
5
4
4
3
3
2
1
1
1
1
1
Reactivity
Human
162
32
8
1
1
1
Host
Mouse
99
85
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
7
6
6
6
6
1
1
1
Application
ELISA, Western Blotting (WB)
145
76
44
26
18
3
3
2
1
1
1
Supplier
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Immunogen NKX3-1 (NP_006158, 100 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C1
Isotype IgG2b kappa
Specificity NKX3-1 (NP_006158, 100 a.a. ~ 210 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name NKX3-1 (NKX3-1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 26350 DA
Gene ID 12406
NCBI Accession NP_006158
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: The homeodomain-containing transcription factor NKX3-1 is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner. Loss of NKX3-1 protein expression is a common finding in human prostate carcinomas and prostatic intraepithelial neoplasia.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-NK3 Homeobox 1 (NKX3-1) (AA 100-210) antibody (ABIN394230) Detection limit for recombinant GST tagged NKX3-1 is approximately 1 ng/mL as a captu...
Background publications Gurel, Ali, Montgomery et al.: "NKX3.1 as a marker of prostatic origin in metastatic tumors." in: The American journal of surgical pathology, Vol. 34, Issue 8, pp. 1097-105, 2010 (PubMed).

Kim, Cheng, Hsu et al.: "Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation." in: The Prostate, Vol. 70, Issue 16, pp. 1729-38, 2010 (PubMed).

Kunderfranco, Mello-Grand, Cangemi et al.: "ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer." in: PLoS ONE, Vol. 5, Issue 5, pp. e10547, 2010 (PubMed).

Bowen, Gelmann: "NKX3.1 activates cellular response to DNA damage." in: Cancer research, Vol. 70, Issue 8, pp. 3089-97, 2010 (PubMed).

Thomas, Preece, Bentel: "Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region." in: The Biochemical journal, Vol. 425, Issue 3, pp. 575-83, 2010 (PubMed).