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Details for Product No. ABIN394231

SRY (Sex Determining Region Y)-Box 9 (SOX9) antibody

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Antigen
Synonyms CMD1, SRA1, CMPD1, 2010306G03Rik, AV220920, mKIAA4243, SOX-9, SOX9, LOC100227849
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394231
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen SOX9 (NP_000337, 400 a.a. ~ 510 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C10
Isotype IgG2a kappa
Specificity SOX9 (NP_000337, 400 a.a. ~ 510 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SOX9
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 56137 DA
Gene ID 12406
UniProt NP_000337
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence
Comment

Background: The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.

Restrictions For Research Use only
Concentration 0.5mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Rao, Fuller, Prieto: "Expression of Sox-9 in metastatic melanoma--a potential diagnostic pitfall." in: The American Journal of dermatopathology, Vol. 32, Issue 3, pp. 262-6, 2010 (PubMed).

Thomsen, Ambroisine, Wynn et al.: "SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation." in: Cancer research, Vol. 70, Issue 3, pp. 979-87, 2010 (PubMed).

Masuda, Esumi: "SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 26933-44, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Alternatives for antigen "SRY (Sex Determining Region Y)-Box 9 (SOX9)", type "Antibodies"
Hosts (99), (21), (5)
Reactivities (117), (44), (27), (27), (26), (25), (25), (2), (1), (1), (1)
Applications (78), (59), (48), (32), (21), (20), (13), (8), (5), (4), (4)
Conjugates (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (22), (9), (7), (7), (6), (6), (6), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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