|+1 404 474 4654|
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RECQL2 (ARABIDOPSIS RECQ HELICASE L2); 3'-5' DNA Helicase/ ATP-Dependent Helicase/ Four-Way Junction Helicase/ Protein Binding (RECQL2) antibody
|Synonyms||RECQ3, RECQL2, RECQL3, DKFZp686C2056, ARABIDOPSIS RECQ HELICASE L2, ARABIDOPSIS THALIANA RECQ 2, ATRECQ2, T19E23.16, T19E23_16, xBLM, recq2, recql2, recql3|
Alternatives ELISA, Immunofluorescence (IF), Western Blotting (WB)
|5 references available|
|Price||450.00 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||WRN (NP_000544, 1322 a.a. ~ 1433 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
|Description||Other names: RECQ3, RECQL2, RECQL3 Werner syndrome|
|Characteristics||Purified Mouse Monoclonal Antibody (Mab)|
|Specificity||WRN (NP_000544, 1322 a.a. ~ 1433 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Molecular Weight||162495 DA|
Background: This gene encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by premature aging.
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000 Immunofluorescence|
|Buffer||Clear, colorless solution in phosphate buffered saline, pH 7.2 .|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Transcription Factors, Signaling, Metabolism, Cell Structure|
|Restrictions||For Research Use only|
Olson, Wang, Pankratz et al.: "Centrosome-related genes, genetic variation, and risk of breast cancer." in: Breast cancer research and treatment, Vol. 125, Issue 1, pp. 221-8, 2010 (PubMed).
Perry, Asaithamby, Barnebey et al.: "Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25699-707, 2010 (PubMed).
Briggs, Goldstein, McCauley et al.: "Variation within DNA repair pathway genes and risk of multiple sclerosis." in: American journal of epidemiology, Vol. 172, Issue 2, pp. 217-24, 2010 (PubMed).
Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).
Ehrenberg, Dratviman-Storobinsky, Avraham-Lubin et al.: "Lack of association of the WRN C1367T polymorphism with senile cataract in the Israeli population." in: Molecular vision, Vol. 16, pp. 1771-5, 2010 (PubMed).
|Hosts||Rabbit (11), Mouse (3)|
|Applications||Western Blotting (WB) (12), Immunoprecipitation (IP) (7), ELISA (2), Flow Cytometry (FACS) (2), Immunocytochemistry (ICC) (2), Immunofluorescence (IF) (1), Immunohistochemistry (IHC) (1)|
|Epitopes||AA 1400-1432 (1), AA 223-237 (1), AA 400-450 (1), C-Term (1), Center, Thr802 (1)|