You are viewing an incomplete version of our website. Please click to reload the website as full version.

HNF4A antibody (Hepatocyte Nuclear Factor 4, alpha) (AA 324-424)

Details for Product anti-HNF4A Antibody No. ABIN394242, Supplier: Log in to see
Antigen
  • CG9310
  • dHNF-4
  • dHNF4
  • Dmel\\CG9310
  • DmHNF4
  • fb58h09
  • Hnf-4
  • HNF-4
  • HNF-4(D)
  • HNF-4alpha
  • Hnf-4h
  • Hnf4
  • hnf4
  • HNF4
  • HNF4A
  • HNF4a7
  • HNF4a8
  • HNF4a9
  • HNF4alpha
  • Hnf4alpha
  • id:ibd1279
  • MODY
  • MODY1
  • Nr2a1
  • NR2A1
  • nr2a1
  • NR2A4
  • NR2A21
  • TCF
  • Tcf14
  • TCF14
  • wu:fb58h09
Alternatives
anti-Human HNF4A antibody for Western Blotting
Epitope
AA 324-424
26
19
13
12
10
9
8
7
6
5
5
5
5
4
4
3
3
3
3
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
180
50
44
10
7
6
4
1
1
1
1
1
1
1
Host
Mouse
131
34
20
Clonality (Clone)
Monoclonal ()
Conjugate
This HNF4A antibody is un-conjugated
5
5
4
4
4
4
1
Application
Immunofluorescence (IF), Western Blotting (WB)
170
88
35
29
19
14
4
4
3
3
2
2
1
1
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Immunogen HNF4A (NP_000448, 324 a.a. ~ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3C6
Isotype IgG2a kappa
Specificity HNF4A (NP_000448, 324 a.a. ~ 424 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HNF4A (HNF4A Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 52785 DA
Gene ID 12406
NCBI Accession NP_000448
Research Area Transcription Factors, Signaling, Cell Structure
Pathways AMPK Signaling, Nuclear Receptor Transcription Pathway
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants.

Restrictions For Research Use only
Concentration 0.5mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-HNF4A antibody (Hepatocyte Nuclear Factor 4, alpha) (AA 324-424) (ABIN394242) Immunofluorescence of monoclonal antibody to HNF4A on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-HNF4A antibody (Hepatocyte Nuclear Factor 4, alpha) (AA 324-424) (ABIN394242) anti-Hepatocyte Nuclear Factor 4, alpha (HNF4A) (AA 324-424) antibody (Image 2)
Background publications Jablonski, McAteer, de Bakker, Franks, Pollin, Hanson, Saxena, Fowler, Shuldiner, Knowler, Altshuler, Florez: "Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program." in: Diabetes, Vol. 59, Issue 10, pp. 2672-81, 2010 (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Chen, Zhang, Liu, Zhou, Zhao, Yang, He, Xu: "Variants in hepatocyte nuclear factor 4alpha gene promoter region and type 2 diabetes risk in Chinese." in: Experimental biology and medicine (Maywood, N.J.), Vol. 235, Issue 7, pp. 857-61, 2010 (PubMed).

de Boussac, Ratajewski, Sachrajda, Köblös, Tordai, Pulaski, Buday, Váradi, Arányi: "The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes." in: The Journal of biological chemistry, Vol. 285, Issue 30, pp. 22800-8, 2010 (PubMed).

Ruchat, Vohl, Weisnagel, Rankinen, Bouchard, Pérusse: "Combining genetic markers and clinical risk factors improves the risk assessment of impaired glucose metabolism." in: Annals of medicine, Vol. 42, Issue 3, pp. 196-206, 2010 (PubMed).