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DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 (DDX6) (AA 1-484) antibody

Details for Product No. ABIN394255
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Antigen
Synonyms si:ch211-147p17.1, P54H, Xp54, hlr2, me31b, p54, rck, HLR2, P54, RCK, p54h, RGD1564560, 1110001P04Rik, E230023J21Rik, mRCK/P54
Epitope
AA 1-484
(14), (8), (7), (6), (4), (3), (2), (1), (1), (1), (1), (1)
Reactivity
Human
(44), (10), (9), (3), (1), (1), (1)
Host
Mouse
(39), (5), (2)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(44), (23), (13), (8), (4), (4), (2), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394255
450.00 $
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Immunogen DDX6 (AAH65007, 1 a.a. ~ 484 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D2
Isotype IgG1 kappa
Specificity DDX6 (AAH65007, 1 a.a. ~ 484 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DDX6
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 54417 DA
Gene ID 12406
Research Area Translation Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the DEAD box protein family. The protein is an RNA helicase found in P-bodies and stress granules, and functions in translation suppression and mRNA degradation. It is required for microRNA-induced gene silencing.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 (DDX6) (AA 1-484) antibody Western Blot analysis of DDX6 expression in transfected 293T cell line by DDX6 monoclonal antibody (M01), clone 3D2. Lane 1: DDX6 transfected lysate(53.2 KDa). Lane 2: Non-transfected lysate. Western blot analysis of DDX6 over-expressed 293 cell line, cotransfected with DDX6 Validated Chimera RNAi used as specificity and loading control.
anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 (DDX6) (AA 1-484) antibody (2) anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 (DDX6) (AA 1-484) antibody (Image 2)
Background publications Tritschler, Braun, Eulalio et al.: "Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B." in: Molecular cell, Vol. 33, Issue 5, pp. 661-8, 2009 (PubMed).

Minshall, Kress, Weil et al.: "Role of p54 RNA helicase activity and its C-terminal domain in translational repression, P-body localization and assembly." in: Molecular biology of the cell, Vol. 20, Issue 9, pp. 2464-72, 2009 (PubMed).

Han, Zheng, Cui et al.: "Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus...." in: Nature genetics, Vol. 41, Issue 11, pp. 1234-7, 2009 (PubMed).

Lind, Macgregor, Vink et al.: "A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations." in: Twin research and human genetics : the official journal of the International Society for Twin Studies, Vol. 13, Issue 1, pp. 10-29, 2010 (PubMed).

Jangra, Yi, Lemon: "DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation." in: Journal of virology, Vol. 84, Issue 13, pp. 6810-24, 2010 (PubMed).

Validation Images
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