Peripheral-Type Benzodiazepine Receptor (TSPO) (AA 1-170) antibody

Details for Product No. ABIN394266, Supplier: Log in to see
Antigen
  • LOC732875
  • LOC100136652
  • LOC100280949
  • BZRP
  • TSPO
  • Bzrp
  • IBP
  • PBR
  • Tspo1
  • MBR
  • PTBZR02
  • Ptbzr
  • RATPTBZR02
  • BPBS
  • DBI
  • PBS
  • PKBS
  • PTBR
  • mDRC
  • pk18
  • peripheral-type benzodiazepine receptor
  • Peripheral-type benzodiazepine receptor
  • translocator protein
  • translocator protein (18kDa)
  • translocator protein-like
  • LOC732875
  • MAV_3896
  • xccb100_2086
  • Smp_102510
  • Sros_1911
  • LOC100136652
  • LOC100280949
  • PGTG_16395
  • PBR
  • Tspo
  • TSPO
  • LOC100338710
Alternatives
anti-Human Peripheral-Type Benzodiazepine Receptor antibody for Immunohistochemistry
Epitope
AA 1-170
36
12
4
2
1
1
1
Reactivity
Human
51
33
12
Host
Mouse
38
25
7
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
3
3
2
2
2
2
Application
ELISA, Western Blotting (WB)
62
41
27
12
5
3
2
2
1
1
1
Options
Supplier
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Supplier Product No.
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Immunogen BZRP (AAH01110, 1 a.a. ~ 170 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D8-B2
Isotype IgG1 kappa
Specificity BZRP (AAH01110, 1 a.a. ~ 170 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BZRP (TSPO Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18779 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Pathways Cellular Response to Molecule of Bacterial Origin
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-Peripheral-Type Benzodiazepine Receptor (TSPO) (AA 1-170) antibody (ABIN394266) Detection limit for recombinant GST tagged BZRP is approximately 10 ng/mL as a captur...
Background publications Nagler, Ben-Izhak, Savulescu, Krayzler, Akrish, Leschiner, Otradnov, Zeno, Veenman, Gavish: "Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis." in: Biochimica et biophysica acta, Vol. 1802, Issue 5, pp. 454-61, 2010 (PubMed).

Guey, García-Closas, Murta-Nascimento, Lloreta, Palencia, Kogevinas, Rothman, Vellalta, Calle, Marenne, Tardón, Carrato, García-Closas, Serra, Silverman, Chanock, Real, Malats: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Costa, Pini, Gabelloni, Da Pozzo, Abelli, Lari, Preve, Lucacchini, Cassano, Martini: "The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals." in: Endocrinology, Vol. 150, Issue 12, pp. 5438-45, 2009 (PubMed).

Fafalios, Akhavan, Parwani, Bies, McHugh, Pflug: "Translocator protein blockade reduces prostate tumor growth." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 19, pp. 6177-84, 2009 (PubMed).

Costa, Pini, Martini, Abelli, Gabelloni, Landi, Muti, Gesi, Lari, Cardini, Galderisi, Mucci, Lucacchini, Cassano: "Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression." in: Psychiatric genetics, Vol. 19, Issue 2, pp. 110-1, 2009 (PubMed).

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