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Peripheral-Type Benzodiazepine Receptor (TSPO) (AA 1-170) antibody

Details for Product No. ABIN394266
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Antigen
Synonyms LOC732875, LOC100136652, LOC100280949, BZRP, TSPO, Bzrp, IBP, PBR, Tspo1, MBR, PTBZR02, Ptbzr, RATPTBZR02, BPBS, DBI, PBS, PKBS, PTBR, mDRC, pk18
Epitope
AA 1-170
(11), (4), (1)
Reactivity
Human
(31), (21), (17), (12), (12)
Host
Mouse
(19), (12), (4), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(23), (14), (11), (10), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
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Catalog No. ABIN394266
450.00 $
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Immunogen BZRP (AAH01110, 1 a.a. ~ 170 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3D8-B2
Isotype IgG1 kappa
Specificity BZRP (AAH01110, 1 a.a. ~ 170 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name BZRP
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 18779 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Peripheral-Type Benzodiazepine Receptor (TSPO) (AA 1-170) antibody Detection limit for recombinant GST tagged BZRP is approximately 10 ng/mL as a capture antibody.
Background publications Costa, Pini, Martini et al.: "Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression." in: Psychiatric genetics, Vol. 19, Issue 2, pp. 110-1, 2009 (PubMed).

Guey, García-Closas, Murta-Nascimento et al.: "Genetic susceptibility to distinct bladder cancer subphenotypes." in: European urology, Vol. 57, Issue 2, pp. 283-92, 2010 (PubMed).

Fafalios, Akhavan, Parwani et al.: "Translocator protein blockade reduces prostate tumor growth." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 19, pp. 6177-84, 2009 (PubMed).

Costa, Pini, Gabelloni et al.: "The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals." in: Endocrinology, Vol. 150, Issue 12, pp. 5438-45, 2009 (PubMed).

Nagler, Ben-Izhak, Savulescu et al.: "Oral cancer, cigarette smoke and mitochondrial 18kDa translocator protein (TSPO) - In vitro, in vivo, salivary analysis." in: Biochimica et biophysica acta, Vol. 1802, Issue 5, pp. 454-61, 2010 (PubMed).

Validation Images
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