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E2F Transcription Factor 8 (E2F8) (AA 1-432) antibody

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Synonyms MGC130750, E2F8, E2F-8, RGD1308091, 4432406C08Rik, AA410048
AA 1-432
(13), (3), (2), (2), (2), (2), (1), (1), (1), (1)
(43), (13), (12), (3), (2), (2), (2), (2), (2), (1), (1)
(25), (14), (4)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1), (1)
ELISA, Western Blotting (WB)
(25), (22), (6), (2), (1)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen E2F8 (AAH28244, 1 a.a. ~ 432 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E9-2F5
Isotype IgG1 kappa
Specificity E2F8 (AAH28244, 1 a.a. ~ 432 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name E2F8 (E2F8 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 94166 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Background: E2F transcription factors, such as E2F8, are essential for orchestrating expression of genes required for cell cycle progression and proliferation (Christensen et al., 2005 [PubMed 16179649]).

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Deng, Wang, Zong et al.: "E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation." in: Cancer research, Vol. 70, Issue 2, pp. 782-91, 2010 (PubMed).

Zalmas, Zhao, Graham et al.: "DNA-damage response control of E2F7 and E2F8." in: EMBO reports, Vol. 9, Issue 3, pp. 252-9, 2008 (PubMed).

Christensen, Cloos, Toftegaard et al.: "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription." in: Nucleic acids research, Vol. 33, Issue 17, pp. 5458-70, 2005 (PubMed).

Logan, Graham, Zhao et al.: "E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7." in: Oncogene, Vol. 24, Issue 31, pp. 5000-4, 2005 (PubMed).

Maiti, Li, de Bruin et al.: "Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation." in: The Journal of biological chemistry, Vol. 280, Issue 18, pp. 18211-20, 2005 (PubMed).

Catalog No. ABIN394269
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