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E2F Transcription Factor 8 (E2F8) (AA 1-432) antibody

Details for Product No. ABIN394269, Supplier: Login to see
Antigen
  • MGC130750
  • E2F8
  • E2F-8
  • RGD1308091
  • 4432406C08Rik
  • AA410048
Epitope
AA 1-432
13
3
2
2
2
2
1
1
1
1
Reactivity
Human
43
13
12
3
2
2
2
2
2
1
1
Host
Mouse
25
14
4
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
25
22
6
2
1
Supplier
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Immunogen E2F8 (AAH28244, 1 a.a. ~ 432 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3E9-2F5
Isotype IgG1 kappa
Specificity E2F8 (AAH28244, 1 a.a. ~ 432 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name E2F8 (E2F8 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 94166 DA
Gene ID 12406
Research Area Cell Cycle, Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: E2F transcription factors, such as E2F8, are essential for orchestrating expression of genes required for cell cycle progression and proliferation (Christensen et al., 2005 [PubMed 16179649]).

Restrictions For Research Use only
Concentration 0.5 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Deng, Wang, Zong et al.: "E2F8 contributes to human hepatocellular carcinoma via regulating cell proliferation." in: Cancer research, Vol. 70, Issue 2, pp. 782-91, 2010 (PubMed).

Zalmas, Zhao, Graham et al.: "DNA-damage response control of E2F7 and E2F8." in: EMBO reports, Vol. 9, Issue 3, pp. 252-9, 2008 (PubMed).

Christensen, Cloos, Toftegaard et al.: "Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription." in: Nucleic acids research, Vol. 33, Issue 17, pp. 5458-70, 2005 (PubMed).

Logan, Graham, Zhao et al.: "E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7." in: Oncogene, Vol. 24, Issue 31, pp. 5000-4, 2005 (PubMed).

Maiti, Li, de Bruin et al.: "Cloning and characterization of mouse E2F8, a novel mammalian E2F family member capable of blocking cellular proliferation." in: The Journal of biological chemistry, Vol. 280, Issue 18, pp. 18211-20, 2005 (PubMed).