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SOX9 antibody (SRY (Sex Determining Region Y)-Box 9) (AA 400-510)

Details for Product anti-SOX9 Antibody No. ABIN394274, Supplier: Login to see
Antigen
  • LOC100227849
  • SOX9
  • CMD1
  • CMPD1
  • SRA1
  • SOX-9
  • 2010306G03Rik
  • AV220920
  • mKIAA4243
Alternatives
anti-Human SOX9 antibody for Dot Blot
Epitope
AA 400-510
23
20
19
14
14
14
13
11
9
9
8
6
6
4
4
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
177
45
25
9
5
2
2
1
Host
Mouse
130
45
5
Clonality (Clone)
Monoclonal ()
Conjugate
This SOX9 antibody is un-conjugated
5
5
5
5
4
4
2
2
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
135
82
53
51
43
19
18
13
8
7
5
2
1
1
Supplier
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Immunogen SOX9 (NP_000337, 400 a.a. ~ 510 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F11
Isotype IgG1 kappa
Specificity SOX9 (NP_000337, 400 a.a. ~ 510 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SOX9 (SOX9 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 56137 DA
Gene ID 12406
NCBI Accession NP_000337
Research Area Transcription Factors, Signaling, Cell Structure
Pathways EGFR Signaling Pathway
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SOX9 antibody (SRY (Sex Determining Region Y)-Box 9) (AA 400-510) (ABIN394274) Immunofluorescence of monoclonal antibody to SOX9 on HepG2 cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-SOX9 antibody (SRY (Sex Determining Region Y)-Box 9) (AA 400-510) (ABIN394274) anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) (AA 400-510) antibody (Image 2)
Background publications Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Masuda, Esumi: "SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 26933-44, 2010 (PubMed).

Thomsen, Ambroisine, Wynn et al.: "SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation." in: Cancer research, Vol. 70, Issue 3, pp. 979-87, 2010 (PubMed).

Rao, Fuller, Prieto: "Expression of Sox-9 in metastatic melanoma--a potential diagnostic pitfall." in: The American Journal of dermatopathology, Vol. 32, Issue 3, pp. 262-6, 2010 (PubMed).