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SRY (Sex Determining Region Y)-Box 9 (SOX9) antibody

Details for Product No. ABIN394274
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Antigen
Synonyms CMD1, SRA1, CMPD1, 2010306G03Rik, AV220920, mKIAA4243, SOX-9, SOX9, LOC100227849
Reactivity
Human
(139), (45), (26), (26), (26), (25), (25), (2)
Host
Mouse
(119), (23), (5)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Immunofluorescence (IF), Western Blotting (WB)
(99), (71), (47), (37), (31), (26), (20), (20), (9), (6), (6), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN394274
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen SOX9 (NP_000337, 400 a.a. ~ 510 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3F11
Isotype IgG1 kappa
Specificity SOX9 (NP_000337, 400 a.a. ~ 510 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SOX9
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 56137 DA
Gene ID 12406
UniProt NP_000337
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal.

Restrictions For Research Use only
Concentration 1mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) antibody Immunofluorescence of monoclonal antibody to SOX9 on HepG2 cell (antibody concentration 10 µg/mL). SOX9 monoclonal antibody (M04), clone 3F11 Western Blot analysis of SOX9 expression in HepG2.
anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) antibody (2) anti-SRY (Sex Determining Region Y)-Box 9 (SOX9) antibody (Image 2)
Background publications Rao, Fuller, Prieto: "Expression of Sox-9 in metastatic melanoma--a potential diagnostic pitfall." in: The American Journal of dermatopathology, Vol. 32, Issue 3, pp. 262-6, 2010 (PubMed).

Thomsen, Ambroisine, Wynn et al.: "SOX9 elevation in the prostate promotes proliferation and cooperates with PTEN loss to drive tumor formation." in: Cancer research, Vol. 70, Issue 3, pp. 979-87, 2010 (PubMed).

Masuda, Esumi: "SOX9, through interaction with microphthalmia-associated transcription factor (MITF) and OTX2, regulates BEST1 expression in the retinal pigment epithelium." in: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 26933-44, 2010 (PubMed).

Johnatty, Beesley, Chen et al.: "Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot"." in: PLoS genetics, Vol. 6, Issue 7, pp. e1001016, 2010 (PubMed).

Jugessur, Shi, Gjessing et al.: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Hosts (119), (23), (5)
Reactivities (139), (45), (26), (26), (26), (25), (25), (2)
Applications (99), (71), (47), (37), (31), (26), (20), (20), (9), (6), (6), (1)
Conjugates (4), (4), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (27), (16), (12), (7), (6), (6), (6), (6), (6), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN394274
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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