Zinc Finger Protein ZIC 1 (ZIC1) antibody

Antigen: Zinc Finger Protein ZIC 1 (ZIC1)

Synonyms: ZIC, ZNF201

Clonality: Monoclonal (3F7)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008

Catalog no.: ABIN394292

Additional Information

Alternative name: ZIC1

Gene ID: 7545

UniProt: NP_003403

Immunogen: ZIC1 (NP_003403, 2 a.a. ~ 95 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K

Isotype: IgG Mix kappa

Clone: 3F7

Description: Other names: ZIC, ZNF201 Zic family member 1 (odd-paired homolog, Drosophila)

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: ZIC1 (NP_003403, 2 a.a. ~ 95 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Molecular Weight: 48295 DA

Comments:

Background: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

Application Details

Application Notes: ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000

Purification: Purified

Buffer: Clear, colorless solution in phosphate buffered saline, pH 7.2 .

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cancer, Transcription Factors, Signaling, Cell Structure

Restrictions: For Research Use only

Images

Detection limit for recombinant GST tagged ZIC1 is approximately 0.3ng/ml as a capture antibody.

Publications

Product: Pourebrahim, Van Dam, Bauters et al.: "ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations." in: FEBS letters, Vol. 581, Issue 26, pp. 5122-6, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Arora, Dutkiewicz, Scaria et al.: "Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif." in: RNA (New York, N.Y.), Vol. 14, Issue 7, pp. 1290-6, 2008 (PubMed).

Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Wang, Jin, Wang et al.: "ZIC1 is downregulated through promoter hypermethylation in gastric cancer." in: Biochemical and biophysical research communications, Vol. 379, Issue 4, pp. 959-63, 2009 (PubMed).