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PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100)

Details for Product anti-PARP1 Antibody No. ABIN394297, Supplier: Log in to see
Antigen
  • BEST:LD21673
  • CG17685
  • CG17696
  • CG17718
  • CG40411
  • D.PARP
  • Dm.pARTa
  • Dmel\\CG40411
  • LD21673.3prime
  • PARP
  • PARP-1
  • PARP1
  • dPARP
  • parp
  • ADPRT
  • ADPRT 1
  • ADPRT1
  • ARTD1
  • PPOL
  • pADPRT-1
  • Adprt
  • Parp-1
  • adprt1
  • padprt-1
  • ppol
  • 5830444G22Rik
  • AI893648
  • Adprp
  • Adprt1
  • C80510
  • parp-1
  • sPARP-1
Alternatives
anti-Human PARP1 antibody for Immunohistochemistry (Paraffin-embedded Sections)
Epitope
AA 1-100
67
20
20
20
20
20
20
19
19
19
17
16
15
14
14
12
12
8
6
6
6
6
6
6
6
6
6
5
5
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
382
62
60
12
5
4
4
3
3
1
1
1
1
1
Host
Mouse
387
42
1
Clonality (Clone)
Monoclonal ()
Conjugate
This PARP1 antibody is un-conjugated
25
25
24
24
23
23
2
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
228
215
172
44
43
35
31
21
13
13
9
4
4
3
3
2
1
1
Supplier
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Immunogen PARP1 (AAH37545, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3G4
Isotype IgG2a kappa
Specificity PARP1 (AAH37545, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PARP1 (PARP1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 113084 DA
Gene ID 12406
Research Area Cancer, Cell Cycle, Signaling, Chromatin, Cell Structure
Pathways Apoptosis, Caspase Cascade in Apoptosis, DNA Damage Repair
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100) (ABIN394297) Immunofluorescence of monoclonal antibody to PARP1 on HeLa cell (antibody concentrati...
Immunohistochemistry (IHC) image for anti-PARP1 antibody (Poly (ADP-Ribose) Polymerase 1) (AA 1-100) (ABIN394297) anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) (AA 1-100) antibody (Image 2)
Background publications Lee, Bang, Park et al.: "Lack of association between poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population." in: Rheumatology international, Vol. 32, Issue 1, pp. 91-6, 2012 (PubMed).

Ho-Pun-Cheung, Assenat, Bascoul-Mollevi et al.: "A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 437-43, 2011 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Krishnakumar, Kraus: "The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets." in: Molecular cell, Vol. 39, Issue 1, pp. 8-24, 2010 (PubMed).

Arora, Lindgren, Basu et al.: "Polymorphisms in the base excision repair pathway and graft-versus-host disease." in: Leukemia, Vol. 24, Issue 8, pp. 1470-5, 2010 (PubMed).