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Poly (ADP-Ribose) Polymerase 1 (PARP1) antibody

Details for Product No. ABIN394297
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Antigen
Synonyms
5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1, ADPRT, ADPRT 1, ADPRT1, PARP-1, pADPRT-1, Adprt, Parp-1, BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, D ... show more
5830444G22Rik, AI893648, ARTD1, Adprp, Adprt1, C80510, PARP, PPOL, parp-1, sPARP-1, ADPRT, ADPRT 1, ADPRT1, PARP-1, pADPRT-1, Adprt, Parp-1, BEST:LD21673, CG17685, CG17696, CG17718, CG40411, D.PARP, Dm.pARTa, Dmel\\CG40411, LD21673.3prime, PARP1, dPARP, parp, adprt1, padprt-1, ppol, ART7.1, ART1 show less
Reactivity
Human
(205), (44), (41), (23), (13), (2), (2), (2), (2), (1), (1), (1)
Host
Mouse
(215), (26), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(13), (13), (12), (12), (12), (11), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(138), (113), (85), (44), (27), (23), (17), (17), (10), (9), (7), (1), (1), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394297
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen PARP1 (AAH37545, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3G4
Isotype IgG2a kappa
Specificity PARP1 (AAH37545, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name PARP1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 113084 DA
Gene ID 12406
Research Area Cancer, Cell Cycle, Signaling, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) antibody Immunofluorescence of monoclonal antibody to PARP1 on HeLa cell (antibody concentration 10 µg/mL). PARP1 monoclonal antibody (M01), clone 3G4 Western Blot analysis of PARP1 expression in HeLa NE.
anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) antibody (2) anti-Poly (ADP-Ribose) Polymerase 1 (PARP1) antibody (Image 2)
Background publications Arora, Lindgren, Basu et al.: "Polymorphisms in the base excision repair pathway and graft-versus-host disease." in: Leukemia, Vol. 24, Issue 8, pp. 1470-5, 2010 (PubMed).

Krishnakumar, Kraus: "The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets." in: Molecular cell, Vol. 39, Issue 1, pp. 8-24, 2010 (PubMed).

Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).

Ho-Pun-Cheung, Assenat, Bascoul-Mollevi et al.: "A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 437-43, 2011 (PubMed).

Lee, Bang, Park et al.: "Lack of association between poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population." in: Rheumatology international, Vol. 32, Issue 1, pp. 91-6, 2012 (PubMed).

Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN394297
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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