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Aryl Hydrocarbon Receptor antibody (AHR) (AA 721-821)

Details for Product anti-AHR Antibody No. ABIN394306, Supplier: Log in to see
Antigen
  • Ah
  • Ahh
  • AHR
  • ahr
  • ahr1
  • Ahre
  • bHLHe76
  • In
Epitope
AA 721-821
34
31
25
15
15
10
9
9
8
6
6
6
5
5
4
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
220
93
68
12
3
3
2
2
2
2
1
1
1
Host
Mouse
170
44
24
10
4
Clonality (Clone)
Monoclonal ()
Conjugate
This Aryl Hydrocarbon Receptor antibody is un-conjugated
8
7
7
5
4
4
4
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Application
Western Blotting (WB)
160
115
100
60
60
49
42
28
17
17
16
7
2
2
2
1
1
1
1
Supplier
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Immunogen AHR (NP_001612, 721 a.a. ~ 821 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 3H4
Isotype IgG1 kappa
Specificity AHR (NP_001612, 721 a.a. ~ 821 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name AHR (AHR Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 96147 DA
Gene ID 12406
NCBI Accession NP_001612
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Aryl Hydrocarbon Receptor antibody (AHR) (AA 721-821) (ABIN394306) Western Blot analysis of AHR expression in transfected 293T cell line by AHR monoclon...
Immunohistochemistry (IHC) image for anti-Aryl Hydrocarbon Receptor antibody (AHR) (AA 721-821) (ABIN394306) anti-Aryl Hydrocarbon Receptor (AHR) (AA 721-821) antibody (Image 2)
Background publications Gandhi, Kumar, Burns, Nadeau, Dake, Laroni, Kozoriz, Weiner, Quintana: "Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells." in: Nature immunology, Vol. 11, Issue 9, pp. 846-53, 2010 (PubMed).

Jugessur, Shi, Gjessing, Lie, Wilcox, Weinberg, Christensen, Boyles, Daack-Hirsch, Nguyen, Christiansen, Lidral, Murray: "Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia." in: PLoS ONE, Vol. 5, Issue 7, pp. e11493, 2010 (PubMed).

Tan, Wang, Yang, Boutros, Macaulay, Xu, Chuang, Kosuge, Yamamoto, Takahashi, Wu, Ross, Harper, Ito: "Aryl hydrocarbon receptor is a transcriptional activator of the human breast cancer resistance protein (BCRP/ABCG2)." in: Molecular pharmacology, Vol. 78, Issue 2, pp. 175-85, 2010 (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

Rowlands, Staskal, Gollapudi, Budinsky: "The human AHR: identification of single nucleotide polymorphisms from six ethnic populations." in: Pharmacogenetics and genomics, Vol. 20, Issue 5, pp. 283-90, 2010 (PubMed).