Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) antibody

Details for Product No. ABIN394315
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Synonyms Hey3, Hrt3, hesr3, bHLHb33, HESR3, HEY3, HRT3
(28), (4), (3), (1), (1)
(18), (8), (2)
Clonality (Clone)
Monoclonal ()
Immunofluorescence (IF), Western Blotting (WB)
(24), (14), (9), (4), (2), (2)
Pubmed 5 references available
Catalog no. ABIN394315
Quantity 0.1 mg
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Immunogen HEYL (NP_055386, 221 a.a. ~ 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A11
Isotype IgG2b kappa
Specificity HEYL (NP_055386, 221 a.a. ~ 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HEYL
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 35087 DA
Gene ID 12406
UniProt NP_055386
Research Area Cell Signaling, Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) antibody Immunofluorescence of monoclonal antibody to HEYL on HeLa cell (antibody concentration 10 µg/mL). HEYL monoclonal antibody (M02), clone 4A11. Western Blot analysis of HEYL expression in LNCaP.
anti-Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) antibody (2) anti-Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) antibody (Image 2)
Background publications Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Iso, Kedes, Hamamori: "HES and HERP families: multiple effectors of the Notch signaling pathway." in: Journal of cellular physiology, Vol. 194, Issue 3, pp. 237-55, 2003 (PubMed).

Colland, Jacq, Trouplin et al.: "Functional proteomics mapping of a human signaling pathway." in: Genome research, Vol. 14, Issue 7, pp. 1324-32, 2004 (PubMed).

Kokubo, Miyagawa-Tomita, Johnson: "Hesr, a mediator of the Notch signaling, functions in heart and vessel development." in: Trends in cardiovascular medicine, Vol. 15, Issue 5, pp. 190-4, 2005 (PubMed).

Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Hosts (18), (8), (2)
Reactivities (28), (4), (3), (1), (1)
Applications (24), (14), (9), (4), (2), (2)
Epitopes (6), (5), (5), (2), (1), (1), (1), (1)
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