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Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) (AA 221-327) antibody

Details for Product No. ABIN394315, Supplier: Log in to see
Antigen
  • HESR3
  • HEY3
  • HRT3
  • bHLHb33
  • Hey3
  • Hrt3
  • hesr3
  • fk74e12
  • wu:fk74e12
Epitope
AA 221-327
19
15
8
7
5
3
2
2
Reactivity
Human
51
4
4
1
1
Host
Mouse
26
22
3
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
Immunofluorescence (IF), Western Blotting (WB)
45
35
12
3
3
2
2
1
1
Supplier
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Immunogen HEYL (NP_055386, 221 a.a. ~ 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A11
Isotype IgG2b kappa
Specificity HEYL (NP_055386, 221 a.a. ~ 327 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name HEYL (HEYL Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 35087 DA
Gene ID 12406
NCBI Accession NP_055386
Research Area Cell Signaling, Transcription Factors, Signaling, Cell Structure
Pathways
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) (AA 221-327) antibody (ABIN394315) Immunofluorescence of monoclonal antibody to HEYL on HeLa cell (antibody concentratio...
Immunohistochemistry (IHC) image for anti-Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) (AA 221-327) antibody (ABIN394315) anti-Hairy/enhancer-of-Split Related with YRPW Motif-Like (HEYL) (AA 221-327) antibody (Image 2)
Background publications Rual, Venkatesan, Hao et al.: "Towards a proteome-scale map of the human protein-protein interaction network. ..." in: Nature, Vol. 437, Issue 7062, pp. 1173-8, 2005 (PubMed).

Kokubo, Miyagawa-Tomita, Johnson: "Hesr, a mediator of the Notch signaling, functions in heart and vessel development." in: Trends in cardiovascular medicine, Vol. 15, Issue 5, pp. 190-4, 2005 (PubMed).

Colland, Jacq, Trouplin et al.: "Functional proteomics mapping of a human signaling pathway." in: Genome research, Vol. 14, Issue 7, pp. 1324-32, 2004 (PubMed).

Iso, Kedes, Hamamori: "HES and HERP families: multiple effectors of the Notch signaling pathway." in: Journal of cellular physiology, Vol. 194, Issue 3, pp. 237-55, 2003 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).