SET Domain, Bifurcated 1 (SETDB1) (AA 2-101) antibody

Details for Product No. ABIN394317
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Synonyms SETDB1, NV10069, fc07d03, si:ch211-81a5.6, wu:fc07d03, ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, AU022152, mKIAA0067
AA 2-101
(18), (8), (5), (4), (3), (1), (1), (1), (1), (1), (1), (1)
(85), (28), (16), (10)
(62), (23)
Clonality (Clone)
Monoclonal ()
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Immunofluorescence (IF), Western Blotting (WB)
(73), (40), (18), (10), (8), (8), (6), (5), (4), (3), (3), (1)
Pubmed 5 references available
Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen SETDB1 (NP_036564, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A3
Isotype IgG2a kappa
Specificity SETDB1 (NP_036564, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SETDB1 (SETDB1 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 143157 DA
Gene ID 12406
NCBI Accession NP_036564
Research Area Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-101) antibody (ABIN394317) Immunofluorescence of monoclonal antibody to SETDB1 on HeLa cell (antibody concentrat...
Immunohistochemistry (IHC) image for anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-101) antibody (ABIN394317) anti-SET Domain, Bifurcated 1 (SETDB1) (AA 2-101) antibody (Image 2)
Background publications Mavaddat, Dunning, Ponder et al.: "Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 1, pp. 255-9, 2009 (PubMed).

Van Duyne, Easley, Wu et al.: "Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR." in: Retrovirology, Vol. 5, pp. 40, 2008 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Gao, Yu, Bi et al.: "Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression." in: Molecular and cellular biochemistry, Vol. 305, Issue 1-2, pp. 35-44, 2007 (PubMed).

Ryu, Lee, Hagerty et al.: "ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 50, pp. 19176-81, 2006 (PubMed).

Catalog No. ABIN394317
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