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SET Domain, Bifurcated 1 (SETDB1) antibody

Details for Product No. ABIN394317
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Antigen
Synonyms ESET, H3-K9-HMTase4, KG1T, KMT1E, TDRD21, AU022152, mKIAA0067, SETDB1, NV10069, fc07d03, wu:fc07d03, si:ch211-81a5.6
Reactivity
Human
(66), (28), (15), (12), (12), (12), (10)
Host
Mouse
(41), (25)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunofluorescence (IF), Western Blotting (WB)
(56), (42), (11), (10), (7), (7), (6), (5), (1), (1), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
Shipping to United States (Change)
Availability Will be delivered in 2 to 3 Business Days
Catalog No. ABIN394317
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen SETDB1 (NP_036564, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4A3
Isotype IgG2a kappa
Specificity SETDB1 (NP_036564, 2 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name SETDB1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 143157 DA
Gene ID 12406
UniProt NP_036564
Research Area Transcription Factors, Chromatin, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: This gene encodes a histone methyltransferase. The encoded enzyme catalyzes the reaction of S-adenosyl-L-methionine and histone L-lysine to produce S-adenosyl-L-homocysteine and histone N(6)-methyl-L-lysine. The encoded protein likely functions in transcriptional repression. Alternatively spliced transcript variants have been described.

Restrictions For Research Use only
Concentration 1 mg/ml
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-SET Domain, Bifurcated 1 (SETDB1) antibody Immunofluorescence of monoclonal antibody to SETDB1 on HeLa cell (antibody concentration 10 µg/mL). SETDB1 monoclonal antibody (M07), clone 4A3 Western Blot analysis of SETDB1 expression in SW-13.
anti-SET Domain, Bifurcated 1 (SETDB1) antibody (2) anti-SET Domain, Bifurcated 1 (SETDB1) antibody (Image 2)
Background publications Ryu, Lee, Hagerty et al.: "ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 50, pp. 19176-81, 2006 (PubMed).

Gao, Yu, Bi et al.: "Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression." in: Molecular and cellular biochemistry, Vol. 305, Issue 1-2, pp. 35-44, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Van Duyne, Easley, Wu et al.: "Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR." in: Retrovirology, Vol. 5, pp. 40, 2008 (PubMed).

Mavaddat, Dunning, Ponder et al.: "Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer." in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 1, pp. 255-9, 2009 (PubMed).

Hosts (41), (25)
Reactivities (66), (28), (15), (12), (12), (12), (10)
Applications (56), (42), (11), (10), (7), (7), (6), (5), (1), (1), (1)
Conjugates (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (7), (5), (3), (2), (2), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN394317
450.00 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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