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CENPM antibody (Centromere Protein M) (AA 1-181)

Details for Product anti-CENPM Antibody No. ABIN394336, Supplier: Log in to see
Antigen
  • 2610019I03Rik
  • AI853711
  • bK250D10.2
  • C22orf18
  • CENP-M
  • cenpm
  • Pane1
  • PANE1
  • RGD1307309
  • zgc:123137
Epitope
AA 1-181
8
7
5
2
1
Reactivity
Human
26
1
1
1
1
1
Host
Mouse
14
11
1
Clonality (Clone)
Monoclonal ()
Conjugate
This CENPM antibody is un-conjugated
1
1
1
1
1
1
Application
Immunofluorescence (IF), Western Blotting (WB)
23
11
8
7
6
1
1
Supplier
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Immunogen C22orf18 (AAH00705, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C12-2C8
Isotype IgG1 kappa
Specificity C22orf18 (AAH00705, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name C22orf18 (CENPM Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 19737 DA
Gene ID 12406
Research Area Signaling, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-CENPM antibody (Centromere Protein M) (AA 1-181) (ABIN394336) Immunofluorescence of to MGC861 on HeLa cell . C22orf18 monoclonal antibody (M01), cl...
Immunohistochemistry (IHC) image for anti-CENPM antibody (Centromere Protein M) (AA 1-181) (ABIN394336) anti-Centromere Protein M (CENPM) (AA 1-181) antibody (Image 2)
Background publications Hosgood, Zhang, Shen, Berndt, Vermeulen, Li, Yin, Yeager, Yuenger, Rothman, Chanock, Smith, Lan: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, 2009 (PubMed).

Izuta, Ikeno, Suzuki, Tomonaga, Nozaki, Obuse, Kisu, Goshima, Nomura, Nomura, Yoda: "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 11, Issue 6, pp. 673-84, 2006 (PubMed).

Okada, Cheeseman, Hori, Okawa, McLeod, Yates, Desai, Fukagawa: "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres." in: Nature cell biology, Vol. 8, Issue 5, pp. 446-57, 2006 (PubMed).

Foltz, Jansen, Black, Bailey, Yates, Cleveland: "The human CENP-A centromeric nucleosome-associated complex." in: Nature cell biology, Vol. 8, Issue 5, pp. 458-69, 2006 (PubMed).

Brickner, Evans, Mito, Xuereb, Feng, Nishida, Fairfull, Ferrell, Foon, Hunt, Shabanowitz, Engelhard, Riddell, Warren: "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL." in: Blood, Vol. 107, Issue 9, pp. 3779-86, 2006 (PubMed).