Centromere Protein M (CENPM) antibody

Details for Product No. ABIN394336
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Synonyms C22orf18, CENP-M, PANE1, bK250D10.2, Pane1, AI853711, 2610019I03Rik, RGD1307309, cenpm, zgc:123137, MGC131127
(11), (1), (1), (1)
(8), (3), (1)
Clonality (Clone)
Monoclonal ()
Immunofluorescence (IF), Western Blotting (WB)
(11), (5), (4), (2), (1)
Pubmed 5 references available
Catalog no. ABIN394336
Quantity 0.1 mg
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Immunogen C22orf18 (AAH00705, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4C12-2C8
Isotype IgG1 kappa
Specificity C22orf18 (AAH00705, 1 a.a. ~ 181 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name C22orf18
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 19737 DA
Gene ID 12406
Research Area Signaling, Chromatin, Cell Structure
Application Notes Western blot = 1:500-1000

Background: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPM is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Centromere Protein M (CENPM) antibody Immunofluorescence of to MGC861 on HeLa cell . C22orf18 monoclonal antibody (M01), clone 4C12-2C8 Western Blot analysis of C22orf18 expression in K-562.
anti-Centromere Protein M (CENPM) antibody (2) anti-Centromere Protein M (CENPM) antibody (Image 2)
Background publications Brickner, Evans, Mito et al.: "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL." in: Blood, Vol. 107, Issue 9, pp. 3779-86, 2006 (PubMed).

Foltz, Jansen, Black et al.: "The human CENP-A centromeric nucleosome-associated complex." in: Nature cell biology, Vol. 8, Issue 5, pp. 458-69, 2006 (PubMed).

Okada, Cheeseman, Hori et al.: "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres." in: Nature cell biology, Vol. 8, Issue 5, pp. 446-57, 2006 (PubMed).

Izuta, Ikeno, Suzuki et al.: "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 11, Issue 6, pp. 673-84, 2006 (PubMed).

Hosgood, Zhang, Shen et al.: "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity." in: Occupational and environmental medicine, Vol. 66, Issue 12, pp. 848-53, 2009 (PubMed).

Hosts (8), (3), (1)
Reactivities (11), (1), (1), (1)
Applications (11), (5), (4), (2), (1)
Epitopes (5), (1), (1)
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