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Details for Product No. ABIN394343

Zinc Finger Protein ZIC 1 (ZIC1) antibody

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Antigen
Synonyms ZIC, ZNF201
Reactivity
»Alternatives Human
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB)
Pubmed 5 references available
Catalog no. ABIN394343
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen ZIC1 (NP_003403, 2 a.a. ~ 95 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4D11
Isotype IgG2b kappa
Specificity ZIC1 (NP_003403, 2 a.a. ~ 95 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name ZIC1
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 48295 DA
Gene ID 12406
UniProt NP_003403
Research Area Cancer, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Background publications Pourebrahim, Van Dam, Bauters et al.: "ZIC1 gene expression is controlled by DNA and histone methylation in mesenchymal proliferations." in: FEBS letters, Vol. 581, Issue 26, pp. 5122-6, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Arora, Dutkiewicz, Scaria et al.: "Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif." in: RNA (New York, N.Y.), Vol. 14, Issue 7, pp. 1290-6, 2008 (PubMed).

Baranzini, Wang, Gibson et al.: "Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis." in: Human molecular genetics, Vol. 18, Issue 4, pp. 767-78, 2009 (PubMed).

Wang, Jin, Wang et al.: "ZIC1 is downregulated through promoter hypermethylation in gastric cancer." in: Biochemical and biophysical research communications, Vol. 379, Issue 4, pp. 959-63, 2009 (PubMed).

Alternatives for antigen "Zinc Finger Protein ZIC 1 (ZIC1)", type "Antibodies"
Hosts (26), (13), (1)
Reactivities (39), (16), (13), (12), (12), (12)
Applications (28), (18), (10), (5), (4), (3), (3), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (6), (5), (2), (2), (1), (1), (1)
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