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Chaperonin Containing TCP1, Subunit 5 (Epsilon) (CCT5) (AA 1-542) antibody

Details for Product No. ABIN394351
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Antigen
Synonyms CCT5, Cct5, DKFZp469K0732, CCT-epsilon, CCTE, TCP-1-epsilon, Ccte, TCPE, mKIAA0098, wu:fb54h08, cct5a
Epitope
AA 1-542
(6), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(36), (15), (15), (5), (3), (3), (2), (2), (2), (1), (1)
Host
Mouse
(32), (6), (5)
Clonality (Clone)
Monoclonal ()
Application
Immunofluorescence (IF), Western Blotting (WB)
(39), (16), (13), (9), (7), (6), (6), (3), (2), (1)
Pubmed 5 references available
Quantity 0.1 mg
Options
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Catalog No. ABIN394351
450.00 $
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Immunogen CCT5 (AAH06543, 1 a.a. ~ 542 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4E5-4B1
Isotype IgG1 kappa
Specificity CCT5 (AAH06543, 1 a.a. ~ 542 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name CCT5
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 59671 DA
Gene ID 12406
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000
Comment

Background: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. In addition, three pseudogenes of this gene have been identified.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-Chaperonin Containing TCP1, Subunit 5 (Epsilon) (CCT5) (AA 1-542) antibody Immunofluorescence of monoclonal antibody to CCT5 on HeLa cell (antibody concentration 10 µg/mL). CCT5 monoclonal antibody (M01), clone 4E5-4B1 Western Blot analysis of CCT5 expression in Hela.
anti-Chaperonin Containing TCP1, Subunit 5 (Epsilon) (CCT5) (AA 1-542) antibody (2) anti-Chaperonin Containing TCP1, Subunit 5 (Epsilon) (CCT5) (AA 1-542) antibody (Image 2)
Background publications Zebol, Hewitt, Moretti et al.: "The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1." in: The international journal of biochemistry & cell biology, Vol. 41, Issue 4, pp. 822-7, 2009 (PubMed).

Goudreault, DAmbrosio, Kean et al.: "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein." in: Molecular & cellular proteomics : MCP, Vol. 8, Issue 1, pp. 157-71, 2009 (PubMed).

Rotthier, Baets, De Vriendt et al.: "Genes for hereditary sensory and autonomic neuropathies: a genotype-phenotype correlation." in: Brain : a journal of neurology, Vol. 132, Issue Pt 10, pp. 2699-711, 2009 (PubMed).

Mukherjee, Conway de Macario, Macario et al.: "Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes." in: BMC evolutionary biology, Vol. 10, pp. 64, 2010 (PubMed).

Pinheiro, Bulik, Thornton et al.: "Association study of 182 candidate genes in anorexia nervosa." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 5, pp. 1070-80, 2010 (PubMed).

Validation Images
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