General Transcription Factor IIIA (GTF3A) antibody

Details for Product No. ABIN394365
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Antigen
Synonyms 2010015D03Rik, 2610111I01Rik, 5330403M05Rik, TFIIIA, AP2, GTF3A, gtf3a, zgc:111799
Reactivity
Human
(13), (1)
Host
Mouse
(8), (6)
Clonality (Clone)
Monoclonal ()
Application
ELISA
(11), (10)
Pubmed 5 references available
Catalog no. ABIN394365
Quantity 0.1 mg
Price
450.00 $   Plus shipping costs $45.00
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Immunogen GTF3A (NP_002088, 185 a.a. ~ 275 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 4G4
Isotype IgG2b kappa
Specificity GTF3A (NP_002088, 185 a.a. ~ 275 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name GTF3A
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 41515 DA
Gene ID 12406
UniProt NP_002088
Research Area Translation Factors, Transcription Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: The product of this gene is a zinc finger protein with nine Cis[2]-His[2] zinc finger domains. It functions as an RNA polymerase III transcription factor to induce transcription of the 5S rRNA genes. The protein binds to a 50 bp internal promoter in the 5S genes called the internal control region (ICR), and nucleates formation of a stable preinitiation complex. This complex recruits the TFIIIC and TFIIIB transcription factors and RNA polymerase III to form the complete transcription complex. The protein is thought to be translated using a non-AUG translation initiation site in mammals based on sequence analysis, protein homology, and the size of the purified protein.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
anti-General Transcription Factor IIIA (GTF3A) antibody Detection limit for recombinant GST tagged GTF3A is approximately 0.3 ng/mL as a capture antibody.
Background publications Tsang, Connell, Brown et al.: "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex." in: Genomics, Vol. 88, Issue 3, pp. 333-46, 2006 (PubMed).

Wu, Ma, Brown et al.: "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening." in: Proteomics, Vol. 7, Issue 11, pp. 1775-85, 2007 (PubMed).

Newton-Cheh, Guo, Wang et al.: "Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study." in: BMC medical genetics, Vol. 8 Suppl 1, pp. S7, 2007 (PubMed).

Barbe, Lundberg, Oksvold et al.: "Toward a confocal subcellular atlas of the human proteome." in: Molecular & cellular proteomics : MCP, Vol. 7, Issue 3, pp. 499-508, 2008 (PubMed).

Varghese, Barriere, Carbone et al.: "Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway." in: Molecular and cellular biology, Vol. 28, Issue 17, pp. 5275-87, 2008 (PubMed).

Hosts (8), (6)
Reactivities (13), (1)
Applications (11), (10)
Epitopes (6), (2), (1)
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