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DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 20 (DDX20) (AA 725-825) antibody

Details for Product No. ABIN394405, Supplier: Log in to see
Antigen
  • DDX20
  • DP103
  • GEMIN3
  • dp103
  • Dp103
  • si:dkey-193l3.3
  • wu:fb16g08
  • wu:fb59a11
Epitope
AA 725-825
19
15
5
4
3
3
2
2
2
2
2
2
1
1
1
1
1
1
Reactivity
Human
59
12
8
Host
Mouse
46
15
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
2
2
2
2
2
2
Application
ELISA
53
37
16
12
8
2
2
2
1
Supplier
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Immunogen DDX20 (NP_009135, 725 a.a. ~ 825 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5H5
Isotype IgG2a kappa
Specificity DDX20 (NP_009135, 725 a.a. ~ 825 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DDX20 (DDX20 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 92241 DA
Gene ID 12406
NCBI Accession NP_009135
Research Area Translation Factors, Signaling, Cell Structure
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 20 (DDX20) (AA 725-825) antibody (ABIN394405) Detection limit for recombinant GST tagged DDX20 is approximately 0.3 ng/mL as a capt...
Background publications Todd, Morse, Shaw et al.: "SMN, Gemin2 and Gemin3 associate with beta-actin mRNA in the cytoplasm of neuronal cells in vitro." in: Journal of molecular biology, Vol. 401, Issue 5, pp. 681-9, 2010 (PubMed).

Boni, Zarate, Villa et al.: "Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 429-36, 2011 (PubMed).

Wilker, Baccarelli, Suh et al.: "Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes." in: Environmental health perspectives, Vol. 118, Issue 7, pp. 943-8, 2010 (PubMed).

Svendsen, Smogorzewska, Sowa et al.: "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair." in: Cell, Vol. 138, Issue 1, pp. 63-77, 2009 (PubMed).

Ye, Wang, Gu et al.: "Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk." in: Cancer prevention research (Philadelphia, Pa.), Vol. 1, Issue 6, pp. 460-9, 2009 (PubMed).