DDX20 antibody (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 20) (AA 725-825)

Details for Product anti-DDX20 Antibody No. ABIN394405, Supplier: Log in to see
Antigen
  • DDX20
  • DP103
  • GEMIN3
  • dp103
  • Dp103
  • si:dkey-193l3.3
  • wu:fb16g08
  • wu:fb59a11
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
  • DDX20
  • ddx20
  • Ddx20
Alternatives
anti-Human DDX20 antibody for Cytometry by Time of Flight
Epitope
AA 725-825
12
10
8
5
5
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4
4
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3
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
108
35
19
3
3
2
1
1
1
Host
Mouse
57
52
Clonality (Clone)
Monoclonal ()
Conjugate
This DDX20 antibody is un-conjugated
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
ELISA
95
74
51
39
21
10
9
7
2
1
1
Options
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Available images

Immunogen DDX20 (NP_009135, 725 a.a. ~ 825 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5H5
Isotype IgG2a kappa
Specificity DDX20 (NP_009135, 725 a.a. ~ 825 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Alternative Name DDX20 (DDX20 Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 92241 DA
Gene ID 12406
NCBI Accession NP_009135
Research Area Translation Factors, Signaling, Cell Structure
Pathways Ribonucleoprotein Complex Subunit Organization
Application Notes ELISA ~~ 1ug/ml~3ng/ml
Comment

Background: DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
ELISA image for anti-DDX20 antibody (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 20) (AA 725-825) (ABIN394405) Detection limit for recombinant GST tagged DDX20 is approximately 0.3 ng/mL as a capt...
Background publications Boni, Zarate, Villa, Bandrés, Gomez, Maiello, Garcia-Foncillas, Aranda: "Role of primary miRNA polymorphic variants in metastatic colon cancer patients treated with 5-fluorouracil and irinotecan." in: The pharmacogenomics journal, Vol. 11, Issue 6, pp. 429-36, 2011 (PubMed).

Todd, Morse, Shaw, McGinley, Stebbings, Young: "SMN, Gemin2 and Gemin3 associate with beta-actin mRNA in the cytoplasm of neuronal cells in vitro." in: Journal of molecular biology, Vol. 401, Issue 5, pp. 681-9, 2010 (PubMed).

Wilker, Baccarelli, Suh, Vokonas, Wright, Schwartz: "Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes." in: Environmental health perspectives, Vol. 118, Issue 7, pp. 943-8, 2010 (PubMed).

Svendsen, Smogorzewska, Sowa, OConnell, Gygi, Elledge, Harper: "Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair." in: Cell, Vol. 138, Issue 1, pp. 63-77, 2009 (PubMed).

Ye, Wang, Gu, Yang, Lin, Ajani, Wu: "Genetic variations in microRNA-related genes are novel susceptibility loci for esophageal cancer risk." in: Cancer prevention research (Philadelphia, Pa.), Vol. 1, Issue 6, pp. 460-9, 2009 (PubMed).