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T (AA 222-321) antibody

Details for Product No. ABIN394406, Supplier: Login to see New
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AA 222-321
(9), (8), (2), (2), (2), (2), (2), (1)
(23), (3)
(12), (11)
Clonality (Clone)
Monoclonal ()
(1), (1), (1), (1), (1), (1)
Western Blotting (WB)
(20), (12), (7), (4), (2)
Pubmed 5 references available
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Quantity 0.1 mg
Shipping to United States ( )
Availability Will be delivered in 8 to 11 Business Days
Immunogen T (NP_003172, 222 a.a. ~ 321 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 5H8
Isotype IgG2a kappa
Specificity T (NP_003172, 222 a.a. ~ 321 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 47443 DA
Gene ID 12406
NCBI Accession NP_003172
Research Area Transcription Factors, Signaling, Cell Structure
Application Notes Western blot = 1:500-1000

Background: The protein encoded by this gene is an embryonic nuclear transcription factor that binds to a specific DNA element, the palindromic T-site. It binds through a region in its N-terminus, called the T-box, and effects transcription of genes required for mesoderm formation and differentiation. The protein is localized to notochord-derived cells.

Restrictions For Research Use only
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-T (AA 222-321) antibody (ABIN394406) Western blot analysis of T over-expressed 293 cell line, cotransfected with T Validat...
Immunohistochemistry (IHC) image for anti-T (AA 222-321) antibody (ABIN394406) anti-T (AA 222-321) antibody (Image 2)
Background publications Jambhekar, Rekhi, Thorat et al.: "Revisiting chordoma with brachyury, a \new age\" marker: analysis of a validation study on 51 cases."" in: Archives of pathology & laboratory medicine, Vol. 134, Issue 8, pp. 1181-7, 2010 (PubMed).

Docherty, Kovas, Petrill et al.: "Generalist genes analysis of DNA markers associated with mathematical ability and disability reveals shared influence across ages and abilities." in: BMC genetics, Vol. 11, pp. 61, 2010 (PubMed).

Yang, Ng, Alcorta et al.: "T (brachyury) gene duplication confers major susceptibility to familial chordoma." in: Nature genetics, Vol. 41, Issue 11, pp. 1176-8, 2009 (PubMed).

Oakley, Fuhrer, Seethala: "Brachyury, SOX-9, and podoplanin, new markers in the skull base chordoma vs chondrosarcoma differential: a tissue microarray-based comparative analysis." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 21, Issue 12, pp. 1461-9, 2008 (PubMed).

Bondue, Lapouge, Paulissen et al.: "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification." in: Cell stem cell, Vol. 3, Issue 1, pp. 69-84, 2008 (PubMed).

Catalog No. ABIN394406
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